US Guideline Criteria for Human Immunodeficiency Virus Preexposure Prophylaxis: Clinical Considerations and Caveats

Sarah K. Calabrese, Douglas S. Krakower, Tiara C. Willie, Trace S. Kershaw, Kenneth H. Mayer

Research output: Contribution to journalReview articlepeer-review

Abstract

Clinical guidelines for human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) developed by the US Centers for Disease Control and Prevention have been instrumental in the implementation of PrEP in medical practices throughout the country. However, the eligibility criteria contained within may inadvertently limit PrEP access for some patients. We describe the following key considerations and caveats related to these criteria: promotion of a selective vs universal approach to sexual health education involving PrEP; misalignment between criteria stated in the table and text boxes; problematic categorization and confounding of sexual orientation, gender identity, and risk behavior; underemphasis of network/community-level drivers of HIV transmission; oversimplification of serodiscordant risk; and lack of clarity surrounding the relevance of condoms to PrEP eligibility. We offer concrete recommendations to address the identified issues and strengthen future iterations of the guidelines, applying these recommendations in an alternative table of criteria.

Original languageEnglish (US)
Article numberciz046
Pages (from-to)884-889
Number of pages6
JournalClinical Infectious Diseases
Volume69
Issue number5
DOIs
StatePublished - Aug 16 2019
Externally publishedYes

Keywords

  • HIV
  • clinical decision-making
  • patient care
  • preexposure prophylaxis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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