US EPA particulate matter research centers: Summary of research results for 2005-2011

Patrick N. Breysse; Ralph J. Delfino; Francesca Dominici; Alison C.P. Elder; Mark W. Frampton; John R. Froines; Alison S. Geyh; John J. Godleski; Diane R. Gold; Philip K. Hopke; Petros Koutrakis; Ning Li; Günter Oberdörster; Kent E. Pinkerton; Jonathan M. Samet; Mark J. Utell; Anthony S. Wexler

doi:10.1007/s11869-012-0181-8

US EPA particulate matter research centers: Summary of research results for 2005-2011

Patrick N. Breysse, Ralph J. Delfino, Francesca Dominici, Alison C.P. Elder, Mark W. Frampton, John R. Froines, Alison S. Geyh, John J. Godleski, Diane R. Gold, Philip K. Hopke, Petros Koutrakis, Ning Li, Günter Oberdörster, Kent E. Pinkerton, Jonathan M. Samet, Mark J. Utell, Anthony S. Wexler

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

The US Environmental Protection Agency funded five academic research centers in 2005 to address uncertainties in the health effects caused by airborne particulate matter (PM) as suggested by the 1998 National Research Council report, "Research Priorities for Airborne Particulate Matter." The centers employed multidisciplinary teams of epidemiologists, toxicologists, atmospheric scientists, engineers, and chemists to approach four key research themes: susceptibility to PM, biological mechanisms of PM response, exposure-response relationships, and source linkages. This review presents selected accomplishments in these categories from the past 5-year period. Publications from the centers are summarized to provide both an overview of the accomplishments to date and easy reference to much of the original literature published by the centers. Numerous investigators worked together within and across centers to investigate the relationships between atmospheric PM and health effects, including (a) the role of reactive oxygen species, inflammation, the nervous system, and the cardiovascular system, (b) particle characteristics such as size, composition, source, and temporal pattern of exposure, and (c) phenotypic and genotypic characteristics of the population that influence the level of exposure and risk in response to a given exposure.

Original language	English (US)
Pages (from-to)	333-355
Number of pages	23
Journal	Air Quality, Atmosphere and Health
Volume	6
Issue number	2
DOIs	https://doi.org/10.1007/s11869-012-0181-8
State	Published - Jun 2013

Keywords

Acute effects
Air pollution
Biological mechanisms
Chronic effects
Epidemiological associations
Exposure
Particulate matter
Source-health relationships
Susceptibility

ASJC Scopus subject areas

Pollution
Atmospheric Science
Management, Monitoring, Policy and Law
Health, Toxicology and Mutagenesis

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10.1007/s11869-012-0181-8

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Breysse, P. N., Delfino, R. J., Dominici, F., Elder, A. C. P., Frampton, M. W., Froines, J. R., Geyh, A. S., Godleski, J. J., Gold, D. R., Hopke, P. K., Koutrakis, P., Li, N., Oberdörster, G., Pinkerton, K. E., Samet, J. M., Utell, M. J., & Wexler, A. S. (2013). US EPA particulate matter research centers: Summary of research results for 2005-2011. Air Quality, Atmosphere and Health, 6(2), 333-355. https://doi.org/10.1007/s11869-012-0181-8

Breysse, PN, Delfino, RJ, Dominici, F, Elder, ACP, Frampton, MW, Froines, JR, Geyh, AS, Godleski, JJ, Gold, DR, Hopke, PK, Koutrakis, P, Li, N, Oberdörster, G, Pinkerton, KE, Samet, JM, Utell, MJ & Wexler, AS 2013, 'US EPA particulate matter research centers: Summary of research results for 2005-2011', Air Quality, Atmosphere and Health, vol. 6, no. 2, pp. 333-355. https://doi.org/10.1007/s11869-012-0181-8

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title = "US EPA particulate matter research centers: Summary of research results for 2005-2011",

abstract = "The US Environmental Protection Agency funded five academic research centers in 2005 to address uncertainties in the health effects caused by airborne particulate matter (PM) as suggested by the 1998 National Research Council report, {"}Research Priorities for Airborne Particulate Matter.{"} The centers employed multidisciplinary teams of epidemiologists, toxicologists, atmospheric scientists, engineers, and chemists to approach four key research themes: susceptibility to PM, biological mechanisms of PM response, exposure-response relationships, and source linkages. This review presents selected accomplishments in these categories from the past 5-year period. Publications from the centers are summarized to provide both an overview of the accomplishments to date and easy reference to much of the original literature published by the centers. Numerous investigators worked together within and across centers to investigate the relationships between atmospheric PM and health effects, including (a) the role of reactive oxygen species, inflammation, the nervous system, and the cardiovascular system, (b) particle characteristics such as size, composition, source, and temporal pattern of exposure, and (c) phenotypic and genotypic characteristics of the population that influence the level of exposure and risk in response to a given exposure.",

keywords = "Acute effects, Air pollution, Biological mechanisms, Chronic effects, Epidemiological associations, Exposure, Particulate matter, Source-health relationships, Susceptibility",

author = "Breysse, {Patrick N.} and Delfino, {Ralph J.} and Francesca Dominici and Elder, {Alison C.P.} and Frampton, {Mark W.} and Froines, {John R.} and Geyh, {Alison S.} and Godleski, {John J.} and Gold, {Diane R.} and Hopke, {Philip K.} and Petros Koutrakis and Ning Li and G{\"u}nter Oberd{\"o}rster and Pinkerton, {Kent E.} and Samet, {Jonathan M.} and Utell, {Mark J.} and Wexler, {Anthony S.}",

note = "Funding Information: Grant information Although the research described in the article has been funded wholly or in part by the US EPA, it has not been subject to the agency{\textquoteright}s required peer and policy review and, therefore, does not necessarily reflect the views of the agency and no official endorsement should be inferred.",

year = "2013",

month = jun,

doi = "10.1007/s11869-012-0181-8",

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AU - Breysse, Patrick N.

AU - Delfino, Ralph J.

AU - Dominici, Francesca

AU - Elder, Alison C.P.

AU - Frampton, Mark W.

AU - Froines, John R.

AU - Geyh, Alison S.

AU - Godleski, John J.

AU - Gold, Diane R.

AU - Hopke, Philip K.

AU - Koutrakis, Petros

AU - Li, Ning

AU - Oberdörster, Günter

AU - Pinkerton, Kent E.

AU - Samet, Jonathan M.

AU - Utell, Mark J.

AU - Wexler, Anthony S.

N1 - Funding Information: Grant information Although the research described in the article has been funded wholly or in part by the US EPA, it has not been subject to the agency’s required peer and policy review and, therefore, does not necessarily reflect the views of the agency and no official endorsement should be inferred.

PY - 2013/6

Y1 - 2013/6

N2 - The US Environmental Protection Agency funded five academic research centers in 2005 to address uncertainties in the health effects caused by airborne particulate matter (PM) as suggested by the 1998 National Research Council report, "Research Priorities for Airborne Particulate Matter." The centers employed multidisciplinary teams of epidemiologists, toxicologists, atmospheric scientists, engineers, and chemists to approach four key research themes: susceptibility to PM, biological mechanisms of PM response, exposure-response relationships, and source linkages. This review presents selected accomplishments in these categories from the past 5-year period. Publications from the centers are summarized to provide both an overview of the accomplishments to date and easy reference to much of the original literature published by the centers. Numerous investigators worked together within and across centers to investigate the relationships between atmospheric PM and health effects, including (a) the role of reactive oxygen species, inflammation, the nervous system, and the cardiovascular system, (b) particle characteristics such as size, composition, source, and temporal pattern of exposure, and (c) phenotypic and genotypic characteristics of the population that influence the level of exposure and risk in response to a given exposure.

AB - The US Environmental Protection Agency funded five academic research centers in 2005 to address uncertainties in the health effects caused by airborne particulate matter (PM) as suggested by the 1998 National Research Council report, "Research Priorities for Airborne Particulate Matter." The centers employed multidisciplinary teams of epidemiologists, toxicologists, atmospheric scientists, engineers, and chemists to approach four key research themes: susceptibility to PM, biological mechanisms of PM response, exposure-response relationships, and source linkages. This review presents selected accomplishments in these categories from the past 5-year period. Publications from the centers are summarized to provide both an overview of the accomplishments to date and easy reference to much of the original literature published by the centers. Numerous investigators worked together within and across centers to investigate the relationships between atmospheric PM and health effects, including (a) the role of reactive oxygen species, inflammation, the nervous system, and the cardiovascular system, (b) particle characteristics such as size, composition, source, and temporal pattern of exposure, and (c) phenotypic and genotypic characteristics of the population that influence the level of exposure and risk in response to a given exposure.

KW - Acute effects

KW - Air pollution

KW - Biological mechanisms

KW - Chronic effects

KW - Epidemiological associations

KW - Exposure

KW - Particulate matter

KW - Source-health relationships

KW - Susceptibility

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JO - Air Quality, Atmosphere and Health

JF - Air Quality, Atmosphere and Health

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ER -

US EPA particulate matter research centers: Summary of research results for 2005-2011

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Keywords

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