US Cohorts review: The HIV Outpatient Study (HOPS) and the Multicenter AIDS Cohort Study (MACS)

Frank J. Palella, Anne C. Moorman, John T. Brooks, John Phair, Lisa Jacobson, Roger Detels, Joseph Margolick, Charles Rinaldo

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter presents an overview of HIV Outpatient Study (HOPS) and Multicenter AIDS Cohort Study (MACS). HOPS is a prospective observational cohort study that was initiated in 1993 by the US Centers for Disease Control and Prevention (CDC), and is currently expected to continue collecting and analyzing longitudinal data on HIV-infected outpatients until mid-2011. It is the longest-running and only remaining US governmentsponsored multi-site prospective cohort of a diverse spectrum of people living with HIV infection and receiving routine clinical care in the United States. MACS was funded in 1983 by the US National Institute of Allergy and Infectious Disease (NIAID), and recruitment of participants began in early 1984. The initial rationale for funding this epidemiological investigation was to collect specimens that could potentially be of use in identifying an infectious agent as the cause of AIDS and to delineate the natural history of pre-AIDS in men who have sex with men (MSM), the first epidemiologically identified group at high risk of developing the syndrome.

Original languageEnglish (US)
Title of host publicationA Decade of HAART
Subtitle of host publicationThe Development and Global Impact of Highly Active Antiretroviral Therapy
PublisherOxford University Press
ISBN (Electronic)9780191723834
ISBN (Print)9780199225859
StatePublished - Sep 1 2009


  • Cohort studies
  • HIV infection
  • Highly active antiretroviral therapy
  • Infectious agent
  • MSM

ASJC Scopus subject areas

  • Medicine(all)


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