Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease

Michael G. Shlipak, Yongmei Li, Caroline Fox, Josef Coresh, Carl Grunfeld, Mary Whooley

Research output: Contribution to journalArticle

Abstract

Background: A common variant of the UMOD gene was linked with prevalent chronic kidney disease (CKD) in large, genomics consortia. One community-based study found that urine concentrations of the uromodulin protein forecast risk of incident CKD. This study within persons with known coronary artery disease (CAD) evaluated whether uromodulin concentrations could distinguish CKD risk. Methods. In the Heart and Soul Study, the UMOD snp (12917707) was genotyped in 879 individuals with baseline creatinine clearance (CrCl) measured from a 24-hour urine collection. Uromodulin protein was measured from stored urine specimens among a subset of 120 participants, balanced by genotype. Incident CKD cases (N = 102) were defined by an initial CrCl > 70 ml/min and a 5-year follow-up CrCl

Original languageEnglish (US)
Article number2
JournalBMC Nephrology
Volume12
Issue number1
DOIs
StatePublished - 2011

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Uromodulin
Chronic Renal Insufficiency
Coronary Artery Disease
Creatinine
Urine
Urine Specimen Collection
Genomics
Proteins
Genotype
Genes

ASJC Scopus subject areas

  • Nephrology

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Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease. / Shlipak, Michael G.; Li, Yongmei; Fox, Caroline; Coresh, Josef; Grunfeld, Carl; Whooley, Mary.

In: BMC Nephrology, Vol. 12, No. 1, 2, 2011.

Research output: Contribution to journalArticle

Shlipak, Michael G. ; Li, Yongmei ; Fox, Caroline ; Coresh, Josef ; Grunfeld, Carl ; Whooley, Mary. / Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease. In: BMC Nephrology. 2011 ; Vol. 12, No. 1.
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