Urolithogenesis of mixed foreign body stones

S. R. Khan, R. L. Hackett

Research output: Contribution to journalArticlepeer-review

Abstract

Urine of male Sprague-Dawley rats was supersaturated for struvite and often contained struvite crystals. Ethylene glycol administration to these rats resulted in elevation of urinary oxalate and calcium oxalate supersaturation, and induced calcium oxalate crystalluria. Implantation of foreign bodies in their urinary bladders and changing their urinary ambient conditions by administering ethylene glycol for two weeks at two week intervals resulted in the formation of urinary stones of mixed composition containing calcium oxalate and struvite. Crystal-onto-crystal epitaxy did not appear to play any role in the development of these stones.

Original languageEnglish (US)
Pages (from-to)1321-1328
Number of pages8
JournalJournal of Urology
Volume138
Issue number5
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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