TY - JOUR
T1 - Urokinase plasminogen activator is immunocytochemically detectable in squamous cell but not basal cell carcinomas
AU - Miller, Stanley J.
AU - Jensen, Pamela J.
AU - Dzubow, Leonard M.
AU - Lazarus, Gerald S.
PY - 1992/3
Y1 - 1992/3
N2 - The presence of plasminogen activators (PA) in a variety of solid tumors appears to correlate, in a number of instances, with enhanced invasive or metastatic capabilities. In the present study, we have immunocytochemically examined basal cell (BCC) and squamous cell carcinomas (SCC) comprising a spectrum of histologic subtypes for the presence of urokinase-type (uPA) and tissue-type (tPA) PA. Neither uPA nor tPA was noted in any BCC, whether of the nodular, infiltrative, morpheaform, or basosquamous variety. uPA but not tPA was seen in 12 of 16 SCC examined; the tumors lacking uPA were all histologically well differentiated. No relationship between uPA expression and depth of invasion was noted, and uPA was not preferentially expressed at tumor borders. We conclude that uPA presence in SCC may relate to the degree of differentiation.
AB - The presence of plasminogen activators (PA) in a variety of solid tumors appears to correlate, in a number of instances, with enhanced invasive or metastatic capabilities. In the present study, we have immunocytochemically examined basal cell (BCC) and squamous cell carcinomas (SCC) comprising a spectrum of histologic subtypes for the presence of urokinase-type (uPA) and tissue-type (tPA) PA. Neither uPA nor tPA was noted in any BCC, whether of the nodular, infiltrative, morpheaform, or basosquamous variety. uPA but not tPA was seen in 12 of 16 SCC examined; the tumors lacking uPA were all histologically well differentiated. No relationship between uPA expression and depth of invasion was noted, and uPA was not preferentially expressed at tumor borders. We conclude that uPA presence in SCC may relate to the degree of differentiation.
UR - http://www.scopus.com/inward/record.url?scp=0026503405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026503405&partnerID=8YFLogxK
U2 - 10.1111/1523-1747.ep12499803
DO - 10.1111/1523-1747.ep12499803
M3 - Article
C2 - 1545144
AN - SCOPUS:0026503405
SN - 0022-202X
VL - 98
SP - 351
EP - 358
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 3
ER -