Urokinase in experimental vitreous hemorrhage

J. Koziol, G. A. Peyman, D. R. Sanders, J. Vichek, M. F. Goldberg

Research output: Contribution to journalArticlepeer-review

Abstract

Toxicity of intravitreal urokinase was studied by injection of various doses of urokinase in primate eyes. Doses of 22,500 CTA units or less produced no toxic effects on the eye. Higher doses caused retinal degeneration, transient lens opacities, and cloudy vitreous. Urokinase was ineffective in clearing experimentally induced vitreous hemorrhage if injected as early as 24 hours after the intravitreal blood or as late as six months thereafter.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalOphthalmic surgery
Volume6
Issue number3
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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