Urine lateral flow lipoarabinomannan assay for diagnosing active tuberculosis in adults living with HIV

Maunank Shah, Colleen Hanrahan, Zhuo Yu Wang, Karen R. Steingart, Stephen D. Lawn, Claudia Denkinger, Nandini Dendukuri

Research output: Contribution to journalArticle

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: Primary objectives: Our primary objectives are: To assess the accuracy of the urine LF-LAM assay for the diagnosis of active TB disease in adults with HIV who are thought to have TB, at different cut-offvalues for test positivity. To assess the accuracy of LF-LAM used as a screening test for active TB disease in adults with HIV, at different cut-offvalues for test positivity. The role of urine LF-LAM assay could be a replacement test for sputum smear microscopy or sputum Xpert® MTB/RIF or an add-on test to sputum smear microscopy or sputum Xpert® MTB/RIF. To investigate heterogeneity of test accuracy in the included studies. Possible sources of heterogeneity include the following covariates: the threshold used to interpret LF-LAM positivity, CD4 count, clinical setting, and reference standard.

Original languageEnglish (US)
Article numberCD011420
JournalCochrane Database of Systematic Reviews
Volume2014
Issue number12
DOIs
StatePublished - Dec 8 2014

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ASJC Scopus subject areas

  • Pharmacology (medical)

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