Urine angiotensinogen and salt-sensitivity and potassium-sensitivity of blood pressure

Casey M. Rebholz, Jing Chen, Qi Zhao, Ji Chun Chen, Jianxin Li, Jie Cao, Luis Gabriel Navar, Lotuce Lee Hamm, Dongfeng Gu, Jiang He

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Urinary excretion of angiotensinogen [urine angiotensinogen (UAGT)] has been proposed as a biomarker of intrarenal renin-angiotensin system activity. We investigated the association between UAGT and saltsensitivity and potassium-sensitivity of blood pressure (BP) among Genetic Epidemiology Network of Salt Sensitivity study participants. Methods: The intervention consisted of a 7-day lowsodium diet (51.3 mmol sodium/day), 7-day high-sodium diet (307.8 mmol sodium/day), and 7-day high-sodium diet with potassium supplementation (307.8 mmol sodium/day and 60 mmol potassium/day). Twenty-four-hour UAGT was estimated at baseline and at the end of each intervention for 100 randomly selected participants. Results: Median UAGT (μg/24 h) and UAGT-to-creatinine ratio (UAGT/Cr, μg/g) were significantly reduced during the low-sodium and potassium-supplementation interventions and increased during the high-sodium intervention (both P=0.01). Baseline log-transformed UAGT and UAGT/Cr ratio were significantly positively associated with BP at baseline and at the end of each intervention. For example, one standard deviation higher log-UAGT/Cr ratio (1.2μg/g) was associated with a 5.0-mmHg (95% confidence interval 2.3-7.8) higher SBP at the end of the high-sodium intervention, after adjusting for multiple covariates (P=0.003). In addition, one standard deviation higher log-UAGT/Cr ratio was associated with a 1.6-mmHg increase in age-adjusted and sex-adjusted SBP from the low-sodium intervention to the high-sodium intervention (95% confidence interval 0.1- 3.1, P=0.04). This association was no longer statistically significant after multivariable adjustment. Conclusion: These data indicate that elevated UAGT are associated with BP sodium sensitivity. Augmentation of intrarenal renin-angiotensin system activity may play an important role in developing salt-sensitive hypertension.

Original languageEnglish (US)
Pages (from-to)1394-1400
Number of pages7
JournalJournal of hypertension
Volume33
Issue number7
DOIs
StatePublished - 2015

Keywords

  • Angiotensinogen
  • Blood pressure
  • Dietary sodium
  • Hypertension
  • Renin-angiotensin system
  • Salt-sensitivity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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