Urinary Mutagenicity and Colorectal Adenoma Risk

Ulrike Peters, David M. DeMarini, Rashmi Sinha, Lance R. Brooks, Sarah H. Warren, Nilanjan Chatterjee, Nathaniel Rothman

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated urinary mutagenicity and colorectal adenoma risk in a clinic-based, case-control study of currently nonsmoking cases (n = 143) and controls (n = 156). Urinary organics were extracted by C18/methanol from 12-h overnight urine samples, and mutagenicity was determined in Salmonella YG1024 +S9 (Ames test). Adenoma risk was 2.4-fold higher in subjects in the highest versus the lowest quintile of urinary mutagenicity (95% confidence interval = 1.1-5.1). Combining urinary mutagenicity with intake of meat-derived mutagenicity (from our earlier analysis) resulted in a 5.6-fold increase in adenoma risk (95% confidence interval = 2.2-13.9, comparing the highest with the lowest quintile). In our study population, diet may have contributed to mutagenic exposure, which was positively associated with colorectal adenoma risk.

Original languageEnglish (US)
Pages (from-to)1253-1256
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume12
Issue number11 II
StatePublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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