Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study

Maria Grau-Perez, Jinying Zhao, Brandon Pierce, Kevin A. Francesconi, Walter Goessler, Yun Zhu, Qiang An, Jason Umans, Lyle Best, Shelley A. Cole, Ana Navas Acien, Maria Tellez-Plaza

Research output: Contribution to journalArticle

Abstract

Introduction: While several mechanisms may explain metal-related health effects, the exact cellular processes are not fully understood. We evaluated the association between leukocyte telomere length (LTL) and urine arsenic (ΣAs), cadmium (Cd) and tungsten (W) exposure in the Strong Heart Study (SHS, N = 1702) and in the Strong Heart Family Study (SHFS, N = 1793). Methods: Urine metal concentrations were measured using ICP-MS. Arsenic exposure was assessed as the sum of inorganic arsenic, monomethylarsonate and dimethylarsinate levels (ΣAs). LTL was measured by quantitative polymerase chain reaction. Results: In the SHS, median levels were 1.09 for LTL, and 8.8, 1.01 and 0.11 μg/g creatinine for ΣAs, Cd, and W, respectively. In the SHFS, median levels were 1.01 for LTL, and 4.3, 0.44, and 0.10 μg/g creatinine. Among SHS participants, increased urine ΣAs, Cd, and W was associated with shorter LTL. The adjusted geometric mean ratio (95% confidence interval) of LTL per an increase equal to the difference between the percentiles 90th and 10th in metal distributions was 0.85 (0.79, 0.92) for ΣAs, 0.91 (0.84, 1.00) for Cd and 0.93 (0.88, 0.98) for W. We observed no significant associations among SHFS participants. The findings also suggest that the association between arsenic and LTL might be differential depending on the exposure levels or age. Conclusions: Additional research is needed to confirm the association between metal exposures and telomere length.

Original languageEnglish (US)
Pages (from-to)311-318
Number of pages8
JournalEnvironmental Pollution
Volume246
DOIs
StatePublished - Mar 1 2019

Fingerprint

North American Indians
Telomere
Arsenic
Leukocytes
Metals
Cadmium
Urine
Creatinine
Cacodylic Acid
Tungsten
Polymerase chain reaction
Health
Confidence Intervals
Polymerase Chain Reaction
Research

Keywords

  • American Indians
  • Arsenic
  • Cadmium
  • Telomeres
  • Tungsten

ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Urinary metals and leukocyte telomere length in American Indian communities : The Strong Heart and the Strong Heart Family Study. / Grau-Perez, Maria; Zhao, Jinying; Pierce, Brandon; Francesconi, Kevin A.; Goessler, Walter; Zhu, Yun; An, Qiang; Umans, Jason; Best, Lyle; Cole, Shelley A.; Navas Acien, Ana; Tellez-Plaza, Maria.

In: Environmental Pollution, Vol. 246, 01.03.2019, p. 311-318.

Research output: Contribution to journalArticle

Grau-Perez, M, Zhao, J, Pierce, B, Francesconi, KA, Goessler, W, Zhu, Y, An, Q, Umans, J, Best, L, Cole, SA, Navas Acien, A & Tellez-Plaza, M 2019, 'Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study', Environmental Pollution, vol. 246, pp. 311-318. https://doi.org/10.1016/j.envpol.2018.12.010
Grau-Perez, Maria ; Zhao, Jinying ; Pierce, Brandon ; Francesconi, Kevin A. ; Goessler, Walter ; Zhu, Yun ; An, Qiang ; Umans, Jason ; Best, Lyle ; Cole, Shelley A. ; Navas Acien, Ana ; Tellez-Plaza, Maria. / Urinary metals and leukocyte telomere length in American Indian communities : The Strong Heart and the Strong Heart Family Study. In: Environmental Pollution. 2019 ; Vol. 246. pp. 311-318.
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T1 - Urinary metals and leukocyte telomere length in American Indian communities

T2 - The Strong Heart and the Strong Heart Family Study

AU - Grau-Perez, Maria

AU - Zhao, Jinying

AU - Pierce, Brandon

AU - Francesconi, Kevin A.

AU - Goessler, Walter

AU - Zhu, Yun

AU - An, Qiang

AU - Umans, Jason

AU - Best, Lyle

AU - Cole, Shelley A.

AU - Navas Acien, Ana

AU - Tellez-Plaza, Maria

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Introduction: While several mechanisms may explain metal-related health effects, the exact cellular processes are not fully understood. We evaluated the association between leukocyte telomere length (LTL) and urine arsenic (ΣAs), cadmium (Cd) and tungsten (W) exposure in the Strong Heart Study (SHS, N = 1702) and in the Strong Heart Family Study (SHFS, N = 1793). Methods: Urine metal concentrations were measured using ICP-MS. Arsenic exposure was assessed as the sum of inorganic arsenic, monomethylarsonate and dimethylarsinate levels (ΣAs). LTL was measured by quantitative polymerase chain reaction. Results: In the SHS, median levels were 1.09 for LTL, and 8.8, 1.01 and 0.11 μg/g creatinine for ΣAs, Cd, and W, respectively. In the SHFS, median levels were 1.01 for LTL, and 4.3, 0.44, and 0.10 μg/g creatinine. Among SHS participants, increased urine ΣAs, Cd, and W was associated with shorter LTL. The adjusted geometric mean ratio (95% confidence interval) of LTL per an increase equal to the difference between the percentiles 90th and 10th in metal distributions was 0.85 (0.79, 0.92) for ΣAs, 0.91 (0.84, 1.00) for Cd and 0.93 (0.88, 0.98) for W. We observed no significant associations among SHFS participants. The findings also suggest that the association between arsenic and LTL might be differential depending on the exposure levels or age. Conclusions: Additional research is needed to confirm the association between metal exposures and telomere length.

AB - Introduction: While several mechanisms may explain metal-related health effects, the exact cellular processes are not fully understood. We evaluated the association between leukocyte telomere length (LTL) and urine arsenic (ΣAs), cadmium (Cd) and tungsten (W) exposure in the Strong Heart Study (SHS, N = 1702) and in the Strong Heart Family Study (SHFS, N = 1793). Methods: Urine metal concentrations were measured using ICP-MS. Arsenic exposure was assessed as the sum of inorganic arsenic, monomethylarsonate and dimethylarsinate levels (ΣAs). LTL was measured by quantitative polymerase chain reaction. Results: In the SHS, median levels were 1.09 for LTL, and 8.8, 1.01 and 0.11 μg/g creatinine for ΣAs, Cd, and W, respectively. In the SHFS, median levels were 1.01 for LTL, and 4.3, 0.44, and 0.10 μg/g creatinine. Among SHS participants, increased urine ΣAs, Cd, and W was associated with shorter LTL. The adjusted geometric mean ratio (95% confidence interval) of LTL per an increase equal to the difference between the percentiles 90th and 10th in metal distributions was 0.85 (0.79, 0.92) for ΣAs, 0.91 (0.84, 1.00) for Cd and 0.93 (0.88, 0.98) for W. We observed no significant associations among SHFS participants. The findings also suggest that the association between arsenic and LTL might be differential depending on the exposure levels or age. Conclusions: Additional research is needed to confirm the association between metal exposures and telomere length.

KW - American Indians

KW - Arsenic

KW - Cadmium

KW - Telomeres

KW - Tungsten

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