Urinary-free cortisol in depressed patients and controls: Relationship to urinary indices of noradrenergic function

A. Roy, M. Linnoila, F. Karoum, D. Pickar

Research output: Contribution to journalArticle

Abstract

We measured urinary outputs of urinary-free cortisol in 28 medication-free depressed patients and 32 normal controls. Depressed patients had significantly greater urinary outputs of urinary-free cortisol than controls. Also, there were significant correlations among depressed patients, but not among controls, between urinary-free cortisol and urinary outputs of norepinephrine and its metabolite vanillylmandelic acid (VMA). These urinary data extend recent findings suggesting that dysregulation of both the hypothalamic-pituitary-adrenal axis and noradrenergic system occur together in depression.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalPsychological Medicine
Volume18
Issue number1
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

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