Urinary excretion of S-benzylmercapturic acid as an indicator of N-nitroso-N-methylbenzylamine exposure

D. X. Lin, M. Friesen, C. Malaveille, D. E.G. Shuker, H. Bartsch

Research output: Contribution to journalArticle

Abstract

The excretion of S-benzylmercapturic acid (SBzMA) in the urine of rats treated with N-nitroso-N-methylbenzylamine (NMBzA) was determined by gas chromatography-mass spectrometry (GC-MS). The identity of SBzMA in the urine was confirmed by full scan GC-MS. The amount of urinary SBzMA varied with the dose of NMBzA (up to 5 mg/kg) and with rat strain. For the three strains investigated, most of a 2.5 mg/kg dose of SBzMA was excreted within 24 h. Comparison of the levels of this SBzMA excreted by rats treated with equivalent doses of either NMBzA or benzaldehyde indicates that urinary SBzMA is derived mainly from benzylating species resulting from the hydroxylation of the methyl group of NMBzA.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalCancer Letters
Volume57
Issue number3
DOIs
StatePublished - May 24 1991

Keywords

  • N-nitroso-N-methylbenzylamine, gas chromatography-mass spectrometry
  • S-Benzylmercapturic acid
  • rat
  • urine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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