Urinary excretion of pyridoxine and 4‐pyridoxic acid in rheumatoid arthritis

Anne B. McKusick, Roger W. Sherwin, Lynn Grupenhoff Jones, Jeng M. Hsu

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Seven patients with active rheumatoid arthritis excreted significantly less pyridoxine in the urine than controls when patient‐control pairs were fed identical constant diets while receiving no drugs. After a 10 mg. dose of pyridoxine hydrochloride, change in objectively measured stiffness appeared to be inversely related to change in urinary excretion of pyridoxine. The study does not necessarily show that giving rheumatoid arthritics pyridoxine is beneficial.

Original languageEnglish (US)
Pages (from-to)636-653
Number of pages18
JournalArthritis & Rheumatism
Issue number6
StatePublished - Dec 1964

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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