Urinary excretion of hydromorphone and metabolites in humans, rats, dogs, guinea pigs, and rabbits

E. J. Cone, B. A. Phelps, C. W. Gorodetzky

Research output: Contribution to journalArticlepeer-review

Abstract

Hydromorphone was administered as a single dose to humans, rats, dogs, guinea pigs, and rabbits, and timed urinary collections were made. GLC‐mass spectrometric and GLC analyses of the samples revealed the presence of the parent compound and both 6‐hydroxy epimers as metabolites in the urine of all species. Free or conjugated parent drug predominated, while levels of free or conjugated 6β‐hydroxy metabolite were higher than or equal to those of the 6α‐form. The time courses of excretion of drug and metabolites were similar for all species, with the major portion being excreted in the first 24 hr. Generally, free and conjugated drug were undetectable in human urine after 8 and 48 hr, respectively.

Original languageEnglish (US)
Pages (from-to)1709-1713
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume66
Issue number12
DOIs
StatePublished - Dec 1977

Keywords

  • Excretion, urinary—hydromorphone and metabolites, humans, rats, dogs, guinea pigs, and rabbits
  • Hydromorphone and metabolites—urinary excretion in humans, rats, dogs, guinea pigs, and rabbits
  • Metabolites—hydromorphone, urinary excretion in humans, rats, dogs, guinea pigs, and rabbits
  • Narcotic analgesics—hydromorphone and metabolites, urinary excretion in humans, rats, dogs, guinea pigs, and rabbits

ASJC Scopus subject areas

  • Pharmaceutical Science

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