Urinary enzymes and calcium oxalate urolithiasis

S. R. Khan, P. N. Shevock, R. L. Hackett

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Male Sprague-Dawley rats were challenged with various hyperoxaluric agents including ammonium oxalate, hydroxy-L-proline, and ethylene glycol. All treatments resulted in increased urinary oxalate. Associated with hyperoxaluria was an increase in urinary levels of renal enzymes, gamma-glutamyl transpeptidase, N-acetyl-β-glucosaminidase, and alkaline phosphatase. Most of the rats did not demonstrate any significant change in urinary levels of β-galactosidase. There was a highly significant positive correlation between urinary oxalate and N-acetyl-β-glucosaminidase.

Original languageEnglish (US)
Pages (from-to)846-849
Number of pages4
JournalJournal of Urology
Issue number3
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Urology


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