Male Sprague-Dawley rats were challenged with various hyperoxaluric agents including ammonium oxalate, hydroxy-L-proline, and ethylene glycol. All treatments resulted in increased urinary oxalate. Associated with hyperoxaluria was an increase in urinary levels of renal enzymes, gamma-glutamyl transpeptidase, N-acetyl-β-glucosaminidase, and alkaline phosphatase. Most of the rats did not demonstrate any significant change in urinary levels of β-galactosidase. There was a highly significant positive correlation between urinary oxalate and N-acetyl-β-glucosaminidase.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Urology|
|State||Published - 1989|
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