Urinary creatinine excretion, bioelectrical impedance analysis, and clinical outcomes in patients with CKD

The CRIC study

CRIC Study Investigators

Research output: Contribution to journalArticle

Abstract

Background and objectives Previous studies in chronic disease states have demonstrated an association between lower urinary creatinine excretion (UCr) and increased mortality, a finding presumed to reflect the effect of low muscle mass on clinical outcomes. Little is known about the relationship between UCr and other measures of body composition in terms of the ability to predict outcomes of interest. Design, setting, participants, & measurements Using data from the Chronic Renal Insufficiency Cohort (CRIC), the relationship between UCr, fat free mass (FFM) as estimated by bioelectrical impedance analysis, and (in a subpopulation) whole-body dual-energy x-ray absorptiometry assessment of appendicular lean mass were characterized. The associations of UCr and FFM with mortality and ESRD were compared using Cox proportional hazards models. Results A total of 3604 CRIC participants (91% of the full CRIC cohort) with both a baseline UCr and FFM measurement were included; of these, 232 had contemporaneous dual-energy x-ray absorptiometry measurements. Participants were recruited between July 2003 and March 2007. UCr and FFM were modestly correlated (rho=0.50; P

Original languageEnglish (US)
Pages (from-to)2095-2103
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume9
Issue number12
DOIs
StatePublished - 2014
Externally publishedYes

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Electric Impedance
Chronic Renal Insufficiency
Creatinine
Cohort Studies
Fats
X-Rays
Mortality
Body Composition
Proportional Hazards Models
Chronic Kidney Failure
Chronic Disease
Muscles

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Urinary creatinine excretion, bioelectrical impedance analysis, and clinical outcomes in patients with CKD : The CRIC study. / CRIC Study Investigators.

In: Clinical Journal of the American Society of Nephrology, Vol. 9, No. 12, 2014, p. 2095-2103.

Research output: Contribution to journalArticle

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abstract = "Background and objectives Previous studies in chronic disease states have demonstrated an association between lower urinary creatinine excretion (UCr) and increased mortality, a finding presumed to reflect the effect of low muscle mass on clinical outcomes. Little is known about the relationship between UCr and other measures of body composition in terms of the ability to predict outcomes of interest. Design, setting, participants, & measurements Using data from the Chronic Renal Insufficiency Cohort (CRIC), the relationship between UCr, fat free mass (FFM) as estimated by bioelectrical impedance analysis, and (in a subpopulation) whole-body dual-energy x-ray absorptiometry assessment of appendicular lean mass were characterized. The associations of UCr and FFM with mortality and ESRD were compared using Cox proportional hazards models. Results A total of 3604 CRIC participants (91{\%} of the full CRIC cohort) with both a baseline UCr and FFM measurement were included; of these, 232 had contemporaneous dual-energy x-ray absorptiometry measurements. Participants were recruited between July 2003 and March 2007. UCr and FFM were modestly correlated (rho=0.50; P",
author = "{CRIC Study Investigators} and Wilson, {F. Perry} and Dawei Xie and Anderson, {Amanda H.} and Leonard, {Mary B.} and Reese, {Peter P.} and Patrice Delafontaine and Edward Horwitz and Radhakrishna Kallem and Sankar Navaneethan and Akinlolu Ojo and Porter, {Anna C.} and Sondheimer, {James H.} and Sweeney, {H. Lee} and Townsend, {Raymond R.} and Feldman, {Harold I.} and Lawrence Appel and Go, {Alan S.} and Jiang He and Kusek, {John W.} and Lash, {James P.} and Akinlolu Ojo and Mahboob Rahman",
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T1 - Urinary creatinine excretion, bioelectrical impedance analysis, and clinical outcomes in patients with CKD

T2 - The CRIC study

AU - CRIC Study Investigators

AU - Wilson, F. Perry

AU - Xie, Dawei

AU - Anderson, Amanda H.

AU - Leonard, Mary B.

AU - Reese, Peter P.

AU - Delafontaine, Patrice

AU - Horwitz, Edward

AU - Kallem, Radhakrishna

AU - Navaneethan, Sankar

AU - Ojo, Akinlolu

AU - Porter, Anna C.

AU - Sondheimer, James H.

AU - Sweeney, H. Lee

AU - Townsend, Raymond R.

AU - Feldman, Harold I.

AU - Appel, Lawrence

AU - Go, Alan S.

AU - He, Jiang

AU - Kusek, John W.

AU - Lash, James P.

AU - Ojo, Akinlolu

AU - Rahman, Mahboob

PY - 2014

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N2 - Background and objectives Previous studies in chronic disease states have demonstrated an association between lower urinary creatinine excretion (UCr) and increased mortality, a finding presumed to reflect the effect of low muscle mass on clinical outcomes. Little is known about the relationship between UCr and other measures of body composition in terms of the ability to predict outcomes of interest. Design, setting, participants, & measurements Using data from the Chronic Renal Insufficiency Cohort (CRIC), the relationship between UCr, fat free mass (FFM) as estimated by bioelectrical impedance analysis, and (in a subpopulation) whole-body dual-energy x-ray absorptiometry assessment of appendicular lean mass were characterized. The associations of UCr and FFM with mortality and ESRD were compared using Cox proportional hazards models. Results A total of 3604 CRIC participants (91% of the full CRIC cohort) with both a baseline UCr and FFM measurement were included; of these, 232 had contemporaneous dual-energy x-ray absorptiometry measurements. Participants were recruited between July 2003 and March 2007. UCr and FFM were modestly correlated (rho=0.50; P

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