TY - JOUR
T1 - Urinary cadmium excretion is associated with increased synthesis of cortico-And sex steroids in a population study
AU - Bochud, Murielle
AU - Jenny-Burri, Judith
AU - Pruijm, Menno
AU - Ponte, Belen
AU - Guessous, Idris
AU - Ehret, Georg
AU - Petrovic, Dusan
AU - Dudler, Vincent
AU - Haldimann, Max
AU - Escher, Geneviève
AU - Dick, Bernhard
AU - Mohaupt, Markus
AU - Paccaud, Fred
AU - Burnier, Michel
AU - Péchère-Bertschi, Antoinette
AU - Martin, Pierre Yves
AU - Vogt, Bruno
AU - Ackermann, Daniel
N1 - Funding Information:
Financial Support: This study was supported by a grant from the Swiss National Science Foundation [FN 33CM30-124087, Schweizerischer Nationalfonds (SNF), Wildhainweg 3, Postfach 8232, 3001 Bern, Switzerland].
Publisher Copyright:
Copyright © 2018 Endocrine Society.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Context: Urinary cadmium (Cd) excretion is associated with cancer and cardiovascular morbidity. A potential mechanism could be disturbance of steroidogenesis in gonads and adrenal glands. Objective: We tested whether urinary excretion of Cd is correlated with that of cortico-And sex steroid metabolites in the general adult population. Setting: The Swiss Kidney Project on Genes in Hypertension is a multicentric, family-based population study. Measures: Urinary excretions of steroid hormone metabolites and Cd were measured with separate day and night collections. Associations were analyzed by mixed linear models. Results: Urinary Cd and testosterone excretions in men were significantly correlated (respective day and night b values [standard error (SE)], 1.378 [0.242], P<0.0005; and 1.440 [0.333], P<0.0005), but not in women [0.333(0.257), P = 0.2; and 0.674 (0.361), P = 0.06]. Urinary Cd and cortisol excretions were positively associated in both sexes [day: b = 0.475 (SE, 0.157), P = 0.0025, and 0.877 (SE, 0.194), P , 0.0005, respectively; night: b = 0.875 (SE, 0.253), P < 0.0005 and 1.183 (SE, 0.277), P = 0.00002, respectively]. Cd excretion was correlated with mineralocorticoid metabolites excretion, except tetrahydroaldosterone, in both sexes (P < 0.01). There was an independent effect of Cd on sex hormone and corticosteroid synthesis and an interdependent effect on gluco-And mineralcorticoid production. Conclusion: Our findings provide evidence for a global stimulating effect on steroid synthesis already at low-dose Cd exposure. These findings might explain the association of Cd with diseases such as steroid-sensitive cancers or metabolic disorders.
AB - Context: Urinary cadmium (Cd) excretion is associated with cancer and cardiovascular morbidity. A potential mechanism could be disturbance of steroidogenesis in gonads and adrenal glands. Objective: We tested whether urinary excretion of Cd is correlated with that of cortico-And sex steroid metabolites in the general adult population. Setting: The Swiss Kidney Project on Genes in Hypertension is a multicentric, family-based population study. Measures: Urinary excretions of steroid hormone metabolites and Cd were measured with separate day and night collections. Associations were analyzed by mixed linear models. Results: Urinary Cd and testosterone excretions in men were significantly correlated (respective day and night b values [standard error (SE)], 1.378 [0.242], P<0.0005; and 1.440 [0.333], P<0.0005), but not in women [0.333(0.257), P = 0.2; and 0.674 (0.361), P = 0.06]. Urinary Cd and cortisol excretions were positively associated in both sexes [day: b = 0.475 (SE, 0.157), P = 0.0025, and 0.877 (SE, 0.194), P , 0.0005, respectively; night: b = 0.875 (SE, 0.253), P < 0.0005 and 1.183 (SE, 0.277), P = 0.00002, respectively]. Cd excretion was correlated with mineralocorticoid metabolites excretion, except tetrahydroaldosterone, in both sexes (P < 0.01). There was an independent effect of Cd on sex hormone and corticosteroid synthesis and an interdependent effect on gluco-And mineralcorticoid production. Conclusion: Our findings provide evidence for a global stimulating effect on steroid synthesis already at low-dose Cd exposure. These findings might explain the association of Cd with diseases such as steroid-sensitive cancers or metabolic disorders.
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U2 - 10.1210/jc.2017-01540
DO - 10.1210/jc.2017-01540
M3 - Article
C2 - 29077874
AN - SCOPUS:85041904127
SN - 0021-972X
VL - 103
SP - 748
EP - 758
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 2
ER -