Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization

Shelley Ehrlich, Paige L. Williams, Stacey A. Missmer, Jodi A. Flaws, Katharine F. Berry, Antonia M. Calafat, Xiaoyun Y. Ye, John C. Petrozza, Diane Wright, Russ Hauser

Research output: Contribution to journalArticle

Abstract

Background: Bisphenol A (BPA) is a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins found in numerous consumer products. In experimental animals, BPA increases embryo implantation failure and reduces litter size. Objective: We evaluated the association of urinary BPA concentrations with implantation failure among women undergoing in vitro fertilization (IVF). Methods: We used online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry to measure urinary BPA concentrations in 137 women in a prospective cohort study among women undergoing IVF at the Massachusetts General Hospital Fertility Center in Boston, Massachusetts. We used logistic regression to evaluate the association of cycle-specific urinary BPA concentrations with implantation failure, accounting for correlation among multiple IVF cycles in the same woman using generalized estimating equations. Implantation failure was defined as a negative serum β-human chorionic gonadotropin test (β-hCG <6 IU/L) 17 days after egg retrieval. Results: Among 137 women undergoing 180 IVF cycles, urinary BPA concentrations had a geometric mean (SD) of 1.53 (2.22) μg/L. Overall, 42% (n = 75) of the IVF cycles resulted in implantation failure. In adjusted models, there was an increased odds of implantation failure with higher quartiles of urinary BPA concentrations {odds ratio (OR) 1.02 [95% confidence interval (CI): 0.35, 2.95}, 1.60 (95% CI: 0.70, 3.78), and 2.11 (95% CI: 0.84, 5.31) for quartiles 2, 3, and 4, respectively, compared with the lowest quartile (p-trend = 0.06). Conclusion: There was a positive linear dose-response association between BPA urinary concentrations and implantation failure.

Original languageEnglish (US)
Pages (from-to)978-983
Number of pages6
JournalEnvironmental Health Perspectives
Volume120
Issue number7
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Fertilization in Vitro
Confidence Intervals
Epoxy Resins
Litter Size
bisphenol A
Solid Phase Extraction
Chorionic Gonadotropin
Tandem Mass Spectrometry
Isotopes
General Hospitals
Ovum
Fertility
Cohort Studies
Logistic Models
Odds Ratio
High Pressure Liquid Chromatography
Prospective Studies
Serum

Keywords

  • Bisphenol A
  • Embryo implantation
  • Fertility
  • Human
  • Reproduction
  • Women

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Ehrlich, S., Williams, P. L., Missmer, S. A., Flaws, J. A., Berry, K. F., Calafat, A. M., ... Hauser, R. (2012). Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Environmental Health Perspectives, 120(7), 978-983. https://doi.org/10.1289/ehp.1104307

Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. / Ehrlich, Shelley; Williams, Paige L.; Missmer, Stacey A.; Flaws, Jodi A.; Berry, Katharine F.; Calafat, Antonia M.; Ye, Xiaoyun Y.; Petrozza, John C.; Wright, Diane; Hauser, Russ.

In: Environmental Health Perspectives, Vol. 120, No. 7, 06.2012, p. 978-983.

Research output: Contribution to journalArticle

Ehrlich, S, Williams, PL, Missmer, SA, Flaws, JA, Berry, KF, Calafat, AM, Ye, XY, Petrozza, JC, Wright, D & Hauser, R 2012, 'Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization', Environmental Health Perspectives, vol. 120, no. 7, pp. 978-983. https://doi.org/10.1289/ehp.1104307
Ehrlich, Shelley ; Williams, Paige L. ; Missmer, Stacey A. ; Flaws, Jodi A. ; Berry, Katharine F. ; Calafat, Antonia M. ; Ye, Xiaoyun Y. ; Petrozza, John C. ; Wright, Diane ; Hauser, Russ. / Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. In: Environmental Health Perspectives. 2012 ; Vol. 120, No. 7. pp. 978-983.
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abstract = "Background: Bisphenol A (BPA) is a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins found in numerous consumer products. In experimental animals, BPA increases embryo implantation failure and reduces litter size. Objective: We evaluated the association of urinary BPA concentrations with implantation failure among women undergoing in vitro fertilization (IVF). Methods: We used online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry to measure urinary BPA concentrations in 137 women in a prospective cohort study among women undergoing IVF at the Massachusetts General Hospital Fertility Center in Boston, Massachusetts. We used logistic regression to evaluate the association of cycle-specific urinary BPA concentrations with implantation failure, accounting for correlation among multiple IVF cycles in the same woman using generalized estimating equations. Implantation failure was defined as a negative serum β-human chorionic gonadotropin test (β-hCG <6 IU/L) 17 days after egg retrieval. Results: Among 137 women undergoing 180 IVF cycles, urinary BPA concentrations had a geometric mean (SD) of 1.53 (2.22) μg/L. Overall, 42{\%} (n = 75) of the IVF cycles resulted in implantation failure. In adjusted models, there was an increased odds of implantation failure with higher quartiles of urinary BPA concentrations {odds ratio (OR) 1.02 [95{\%} confidence interval (CI): 0.35, 2.95}, 1.60 (95{\%} CI: 0.70, 3.78), and 2.11 (95{\%} CI: 0.84, 5.31) for quartiles 2, 3, and 4, respectively, compared with the lowest quartile (p-trend = 0.06). Conclusion: There was a positive linear dose-response association between BPA urinary concentrations and implantation failure.",
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AU - Berry, Katharine F.

AU - Calafat, Antonia M.

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