Urinary bisphenol a concentration and thyroid function in Chinese adults

Tiange Wang, Jieli Lu, Min Xu, Yu Xu, Mian Li, Yu Liu, Xiaoguang Tian, Yuhong Chen, Meng Dai, Weiqing Wang, Shenghan Lai, Yufang Bi, Guang Ning

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Bisphenol A (BPA) is an endocrine disruptor that in animal studies can bind to the thyroid hormone receptor and affect thyroid function. Relevant epidemiologic studies are limited and results are inconsistent. We explored the relationship between urinary BPA and thyroid function in a Chinese population. METHODS: The study population included 3394 subjects age 40 years or older who were enrolled in a population-based study from Songnan Community, Baoshan District, Shanghai, China, from June through August 2009. We analyzed the association between urinary BPA and thyroid function using multivariate linear regression. Participants were further divided according to thyroid function status, and logistic regression was applied to determine the relationship between urinary BPA and thyroid function. RESULTS: Each one-quartile increase in BPA was related to an increase of 0.068 pmol/l (95% confidence interval = 0.065- 0.071) in free triiodothyronine and a 0.084 μIU/ml decline (-0.099 to -0.069) in thyroid-stimulating hormone (TSH) in men. For women, there was a 0.10 pmol/l (0.09 to 0.11) increase in free triiodothyronine and a 0.13 μIU/ml decline (-0.14 to -0.11) in TSH. High urinary BPA level was associated with increased thyroid function (adjusted odds ratio= 1.71 [1.26 to 2.32]). CONCLUSIONS: Our results support previous reports of associations between BPA exposure and altered thyroid hormones in animal models and epidemiologic studies. Because our study is cross-sectional, no causal relationships can be established.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalEpidemiology
Volume24
Issue number2
DOIs
StatePublished - Mar 2013

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Thyroid Gland
Triiodothyronine
Thyrotropin
Epidemiologic Studies
Population
Endocrine Disruptors
Thyroid Hormone Receptors
bisphenol A
Thyroid Hormones
Linear Models
China
Animal Models
Cross-Sectional Studies
Logistic Models
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Epidemiology

Cite this

Wang, T., Lu, J., Xu, M., Xu, Y., Li, M., Liu, Y., ... Ning, G. (2013). Urinary bisphenol a concentration and thyroid function in Chinese adults. Epidemiology, 24(2), 295-302. https://doi.org/10.1097/EDE.0b013e318280e02f

Urinary bisphenol a concentration and thyroid function in Chinese adults. / Wang, Tiange; Lu, Jieli; Xu, Min; Xu, Yu; Li, Mian; Liu, Yu; Tian, Xiaoguang; Chen, Yuhong; Dai, Meng; Wang, Weiqing; Lai, Shenghan; Bi, Yufang; Ning, Guang.

In: Epidemiology, Vol. 24, No. 2, 03.2013, p. 295-302.

Research output: Contribution to journalArticle

Wang, T, Lu, J, Xu, M, Xu, Y, Li, M, Liu, Y, Tian, X, Chen, Y, Dai, M, Wang, W, Lai, S, Bi, Y & Ning, G 2013, 'Urinary bisphenol a concentration and thyroid function in Chinese adults', Epidemiology, vol. 24, no. 2, pp. 295-302. https://doi.org/10.1097/EDE.0b013e318280e02f
Wang, Tiange ; Lu, Jieli ; Xu, Min ; Xu, Yu ; Li, Mian ; Liu, Yu ; Tian, Xiaoguang ; Chen, Yuhong ; Dai, Meng ; Wang, Weiqing ; Lai, Shenghan ; Bi, Yufang ; Ning, Guang. / Urinary bisphenol a concentration and thyroid function in Chinese adults. In: Epidemiology. 2013 ; Vol. 24, No. 2. pp. 295-302.
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AU - Li, Mian

AU - Liu, Yu

AU - Tian, Xiaoguang

AU - Chen, Yuhong

AU - Dai, Meng

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N2 - BACKGROUND: Bisphenol A (BPA) is an endocrine disruptor that in animal studies can bind to the thyroid hormone receptor and affect thyroid function. Relevant epidemiologic studies are limited and results are inconsistent. We explored the relationship between urinary BPA and thyroid function in a Chinese population. METHODS: The study population included 3394 subjects age 40 years or older who were enrolled in a population-based study from Songnan Community, Baoshan District, Shanghai, China, from June through August 2009. We analyzed the association between urinary BPA and thyroid function using multivariate linear regression. Participants were further divided according to thyroid function status, and logistic regression was applied to determine the relationship between urinary BPA and thyroid function. RESULTS: Each one-quartile increase in BPA was related to an increase of 0.068 pmol/l (95% confidence interval = 0.065- 0.071) in free triiodothyronine and a 0.084 μIU/ml decline (-0.099 to -0.069) in thyroid-stimulating hormone (TSH) in men. For women, there was a 0.10 pmol/l (0.09 to 0.11) increase in free triiodothyronine and a 0.13 μIU/ml decline (-0.14 to -0.11) in TSH. High urinary BPA level was associated with increased thyroid function (adjusted odds ratio= 1.71 [1.26 to 2.32]). CONCLUSIONS: Our results support previous reports of associations between BPA exposure and altered thyroid hormones in animal models and epidemiologic studies. Because our study is cross-sectional, no causal relationships can be established.

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