Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll-station workers in Taipei, Taiwan

Ching Huang Lai, Saou Hsing Liou, Tung Sheng Shih, Perng Jy Tsai, Hsiao Lung Chen, Timothy J. Buckley, Paul T. Strickland, Jouni J.K. Jaakkola

Research output: Contribution to journalArticle

Abstract

In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 pmol/mol creatinine in the exposed group and 0.073 μmol/mol creatinine in the reference group (difference in mean concentrations: 0.044 μmol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 μmol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 μmol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalArchives of Environmental Health
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2004

Keywords

  • 1-hydroxypyrene-glucuronide
  • Air pollution
  • Biomarkers of exposure
  • Exposure assessment
  • Occupational exposure
  • Polycyclic aromatic hydrocarbons

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll-station workers in Taipei, Taiwan'. Together they form a unique fingerprint.

  • Cite this