Uric acid level and elevated blood pressure in US adolescents: National health and nutrition examination survey, 1999-2006

Research output: Contribution to journalArticle

Abstract

Uric acid is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. We examined the association between uric acid and elevated blood pressure in a large, nationally representative cohort of US adolescents, a population with a relatively low prevalence of cardiovascular disease and cardiovascular disease risk factors. Among 6036 adolescents 12 to 17 years of age examined in the 1999-2006 National Health and Nutrition Examination Survey, the mean age was 14.5 years, 17% were obese (body mass index: ≥95th percentile), and 3.3% had elevated blood pressure. Mean serum uric acid level was 5.0 mg/dL, and 34% had a uric acid level ≥5.5 mg/dL. In analyses adjusted for age, sex, race/ethnicity, and body mass index percentile, the odds ratio of elevated blood pressure, defined as a systolic or diastolic blood pressure ≥95th percentile for age, sex, and height, for each 0.1-mg/dL increase in uric acid level was 1.38 (95% CI: 1.16-1.65). Compared with

Original languageEnglish (US)
Pages (from-to)811-817
Number of pages7
JournalHypertension
Volume59
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Nutrition Surveys
Uric Acid
Blood Pressure
Cardiovascular Diseases
Body Mass Index
Pre-Eclampsia
Chronic Renal Insufficiency
Coronary Artery Disease
Diabetes Mellitus
Stroke
Odds Ratio
Adolescent Health
Hypertension
Serum
Population

Keywords

  • adolescents
  • blood pressure
  • children
  • cross-sectional studies
  • essential hypertension
  • NHANES
  • uric acid

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Uric acid level and elevated blood pressure in US adolescents: National health and nutrition examination survey, 1999-2006",
abstract = "Uric acid is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. We examined the association between uric acid and elevated blood pressure in a large, nationally representative cohort of US adolescents, a population with a relatively low prevalence of cardiovascular disease and cardiovascular disease risk factors. Among 6036 adolescents 12 to 17 years of age examined in the 1999-2006 National Health and Nutrition Examination Survey, the mean age was 14.5 years, 17{\%} were obese (body mass index: ≥95th percentile), and 3.3{\%} had elevated blood pressure. Mean serum uric acid level was 5.0 mg/dL, and 34{\%} had a uric acid level ≥5.5 mg/dL. In analyses adjusted for age, sex, race/ethnicity, and body mass index percentile, the odds ratio of elevated blood pressure, defined as a systolic or diastolic blood pressure ≥95th percentile for age, sex, and height, for each 0.1-mg/dL increase in uric acid level was 1.38 (95{\%} CI: 1.16-1.65). Compared with",
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