TY - JOUR
T1 - Uric acid and inflammatory markers
AU - Ruggiero, Carmelinda
AU - Cherubini, Antonio
AU - Ble, Alessandro
AU - Bos, Angelo J G
AU - Maggio, Marcello
AU - Dixit, Vishwa D.
AU - Lauretani, Fulvio
AU - Bandinelli, Stefania
AU - Senin, Umberto
AU - Ferrucci, Luigi
PY - 2006/5
Y1 - 2006/5
N2 - Aims: The role of uric acid (UA) in the process of atherosclerosis and atherotrombosis is controversial. Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure. Methods and results: We evaluate a relationship between UA levels and several inflammatory markers in 957 subjects, free of severe renal failure, from a representative Italian cohort of persons aged 65-95. Plasma levels of UA and white blood cell (WBC) and neutrophil count, C-reactive protein, interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6r), interleukin-18 (IL-18), and tumor necrosis factor-α (TNF-α) were measured. Complete information on potential confounders was collected using standard methods. WBC (P = 0.0001), neutrophils (P <0.0001), C-reactive protein (P <0.0001), IL-1ra (P <0.0001), IL-6 (P = 0.0004), sIL-6r (P = 0.002), IL-18 (P <0.0001), TNF-α (P = 0.0008), and the percentage of subjects with abnormally high levels of C-reactive protein (P = 0.004) and IL-6 (P =
AB - Aims: The role of uric acid (UA) in the process of atherosclerosis and atherotrombosis is controversial. Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure. Methods and results: We evaluate a relationship between UA levels and several inflammatory markers in 957 subjects, free of severe renal failure, from a representative Italian cohort of persons aged 65-95. Plasma levels of UA and white blood cell (WBC) and neutrophil count, C-reactive protein, interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6r), interleukin-18 (IL-18), and tumor necrosis factor-α (TNF-α) were measured. Complete information on potential confounders was collected using standard methods. WBC (P = 0.0001), neutrophils (P <0.0001), C-reactive protein (P <0.0001), IL-1ra (P <0.0001), IL-6 (P = 0.0004), sIL-6r (P = 0.002), IL-18 (P <0.0001), TNF-α (P = 0.0008), and the percentage of subjects with abnormally high levels of C-reactive protein (P = 0.004) and IL-6 (P =
KW - Comorbidity
KW - Elderly
KW - Inflammation
KW - Metabolism
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U2 - 10.1093/eurheartj/ehi879
DO - 10.1093/eurheartj/ehi879
M3 - Article
C2 - 16611671
AN - SCOPUS:33646748459
SN - 0195-668X
VL - 27
SP - 1174
EP - 1181
JO - European Heart Journal
JF - European Heart Journal
IS - 10
ER -