Uremic lung: New insights into a forgotten condition

Paul J. Scheel; Manchang Liu; Hamid Rabb

doi:10.1038/ki.2008.390

Uremic lung: New insights into a forgotten condition

Paul J. Scheel, Manchang Liu, Hamid Rabb

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

72 Scopus citations

Abstract

The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.

Original language	English (US)
Pages (from-to)	849-851
Number of pages	3
Journal	Kidney international
Volume	74
Issue number	7
DOIs	https://doi.org/10.1038/ki.2008.390
State	Published - Oct 2008

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2008.390

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abstract = "The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.",

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AB - The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.

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Uremic lung: New insights into a forgotten condition

Abstract

ASJC Scopus subject areas

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