Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis: Implications for Diagnostic Imaging of High-Grade Gliomas

Roberto A. Salas Fragomeni; Kenneth J. Pienta; Martin G. Pomper; Michael A. Gorin; Steven P. Rowe

doi:10.1097/RLU.0000000000002280

Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis: Implications for Diagnostic Imaging of High-Grade Gliomas

Roberto A. Salas Fragomeni, Kenneth J. Pienta, Martin G. Pomper, Michael A. Gorin, Steven P. Rowe

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Recent PET imaging of glioblastoma multiforme and other high-grade gliomas using prostate-specific membrane antigen (PSMA)-targeted small-molecule radiotracers suggests a role for these agents in diagnostic imaging of recurrent/residual tumor and that PSMA-targeted endoradiotherapies may provide a new approach to therapy for patients with these difficult-to-treat tumors. We present a case of cerebral radionecrosis demonstrating PSMA-targeted radiotracer uptake. Our findings may represent a potential pitfall and limitation to the diagnostic application of PSMA-targeted agents for high-grade gliomas.

Original language	English (US)
Pages (from-to)	e419-e421
Journal	Clinical nuclear medicine
Volume	43
Issue number	11
DOIs	https://doi.org/10.1097/RLU.0000000000002280
State	Published - Nov 1 2018

Keywords

glioblastoma multiforme
positron emission tomography
prostate-specific membrane antigen

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/RLU.0000000000002280

Cite this

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title = "Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis: Implications for Diagnostic Imaging of High-Grade Gliomas",

abstract = "Recent PET imaging of glioblastoma multiforme and other high-grade gliomas using prostate-specific membrane antigen (PSMA)-targeted small-molecule radiotracers suggests a role for these agents in diagnostic imaging of recurrent/residual tumor and that PSMA-targeted endoradiotherapies may provide a new approach to therapy for patients with these difficult-to-treat tumors. We present a case of cerebral radionecrosis demonstrating PSMA-targeted radiotracer uptake. Our findings may represent a potential pitfall and limitation to the diagnostic application of PSMA-targeted agents for high-grade gliomas.",

keywords = "glioblastoma multiforme, positron emission tomography, prostate-specific membrane antigen",

author = "{Salas Fragomeni}, {Roberto A.} and Pienta, {Kenneth J.} and Pomper, {Martin G.} and Gorin, {Michael A.} and Rowe, {Steven P.}",

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T2 - Implications for Diagnostic Imaging of High-Grade Gliomas

AU - Salas Fragomeni, Roberto A.

AU - Pienta, Kenneth J.

AU - Pomper, Martin G.

AU - Gorin, Michael A.

AU - Rowe, Steven P.

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N2 - Recent PET imaging of glioblastoma multiforme and other high-grade gliomas using prostate-specific membrane antigen (PSMA)-targeted small-molecule radiotracers suggests a role for these agents in diagnostic imaging of recurrent/residual tumor and that PSMA-targeted endoradiotherapies may provide a new approach to therapy for patients with these difficult-to-treat tumors. We present a case of cerebral radionecrosis demonstrating PSMA-targeted radiotracer uptake. Our findings may represent a potential pitfall and limitation to the diagnostic application of PSMA-targeted agents for high-grade gliomas.

AB - Recent PET imaging of glioblastoma multiforme and other high-grade gliomas using prostate-specific membrane antigen (PSMA)-targeted small-molecule radiotracers suggests a role for these agents in diagnostic imaging of recurrent/residual tumor and that PSMA-targeted endoradiotherapies may provide a new approach to therapy for patients with these difficult-to-treat tumors. We present a case of cerebral radionecrosis demonstrating PSMA-targeted radiotracer uptake. Our findings may represent a potential pitfall and limitation to the diagnostic application of PSMA-targeted agents for high-grade gliomas.

KW - glioblastoma multiforme

KW - positron emission tomography

KW - prostate-specific membrane antigen

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Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis: Implications for Diagnostic Imaging of High-Grade Gliomas

Abstract

Keywords

ASJC Scopus subject areas

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