TY - JOUR
T1 - Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis
T2 - Implications for Diagnostic Imaging of High-Grade Gliomas
AU - Salas Fragomeni, Roberto A.
AU - Pienta, Kenneth
AU - Pomper, Martin Gilbert
AU - Gorin, Michael
AU - Rowe, Steven
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Recent PET imaging of glioblastoma multiforme and other high-grade gliomas using prostate-specific membrane antigen (PSMA)-targeted small-molecule radiotracers suggests a role for these agents in diagnostic imaging of recurrent/residual tumor and that PSMA-targeted endoradiotherapies may provide a new approach to therapy for patients with these difficult-to-treat tumors. We present a case of cerebral radionecrosis demonstrating PSMA-targeted radiotracer uptake. Our findings may represent a potential pitfall and limitation to the diagnostic application of PSMA-targeted agents for high-grade gliomas.
AB - Recent PET imaging of glioblastoma multiforme and other high-grade gliomas using prostate-specific membrane antigen (PSMA)-targeted small-molecule radiotracers suggests a role for these agents in diagnostic imaging of recurrent/residual tumor and that PSMA-targeted endoradiotherapies may provide a new approach to therapy for patients with these difficult-to-treat tumors. We present a case of cerebral radionecrosis demonstrating PSMA-targeted radiotracer uptake. Our findings may represent a potential pitfall and limitation to the diagnostic application of PSMA-targeted agents for high-grade gliomas.
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U2 - 10.1097/RLU.0000000000002280
DO - 10.1097/RLU.0000000000002280
M3 - Article
C2 - 30247210
AN - SCOPUS:85054425282
VL - 43
SP - e419-e421
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
SN - 0363-9762
IS - 11
ER -