Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis: Implications for Diagnostic Imaging of High-Grade Gliomas

Roberto A. Salas Fragomeni, Kenneth J. Pienta, Martin G. Pomper, Michael A. Gorin, Steven P. Rowe

Research output: Contribution to journalArticlepeer-review

Abstract

Recent PET imaging of glioblastoma multiforme and other high-grade gliomas using prostate-specific membrane antigen (PSMA)-targeted small-molecule radiotracers suggests a role for these agents in diagnostic imaging of recurrent/residual tumor and that PSMA-targeted endoradiotherapies may provide a new approach to therapy for patients with these difficult-to-treat tumors. We present a case of cerebral radionecrosis demonstrating PSMA-targeted radiotracer uptake. Our findings may represent a potential pitfall and limitation to the diagnostic application of PSMA-targeted agents for high-grade gliomas.

Original languageEnglish (US)
Pages (from-to)e419-e421
JournalClinical nuclear medicine
Volume43
Issue number11
DOIs
StatePublished - Nov 1 2018

Keywords

  • glioblastoma multiforme
  • positron emission tomography
  • prostate-specific membrane antigen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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