Upright posture increases oxyhemoglobin saturation in Peruvian highlanders

At high altitude, hypoxia amplifies oxyhemoglobin saturation (S_PO₂) swings with changes in respiratory mechanics. Our objective was to examine the effects of posture on S_PO₂ and determine predictors of postural S_PO₂ changes in highlanders. 50 native highlanders from Puno, Peru (3825 m) assumed supine and upright-seated postures, in rotating sequence, while undergoing continuous pulse-oximetry. We compared mean S_pO₂ in each posture with a paired t-test. We examined associations of BMI, age, sex and spirometry with postural S_pO₂ changes with mixed-effects linear regression. In highlanders, S_pO₂ was 84% in the supine posture and was 1.0% ± 1.1 (p < 0.0001) greater in the upright-seated posture. Greater postural changes in S_pO₂ were associated with older age (p = 0.01 for interaction) but not with sex, BMI, FVC or FEV₁. In highlanders, S_pO₂ is higher in the upright-seated compared to supine posture, especially with older age. Because we generally sleep flat, posture may contribute significantly to highlanders’ hypoxemic burden during sleep. Postural intervention during sleep may mitigate nocturnal hypoxemia.