Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha

M. De Bruin, K. Smid, M. A. Van Der Ent, M. Fukushima, H. M. Pinedo, G. J. Peters

Research output: Contribution to journalArticlepeer-review

Abstract

Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. TP is known to be regulated by several cytokines and interferons. In our HT29 cell line the TP mRNA and activity expression increased 2-3 fold after treatment with interferon alpha.

Original languageEnglish (US)
Pages (from-to)1367-1370
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume23
Issue number8-9
DOIs
StatePublished - 2004
Externally publishedYes

Keywords

  • Interferon-gamma
  • Platelet derived endothelial cell growth factor
  • Thymidine phosphorylase

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

Fingerprint Dive into the research topics of 'Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha'. Together they form a unique fingerprint.

Cite this