Upregulation of hypoxia-induced mitogenic factor in bacterial lipopolysaccharide-induced acute lung injury

Qiangsong Tong, Liduan Zheng, Qiaohua Kang, Jeffrey M Dodd-o, John Langer, Bo Li, Danming Wang, Dechun Li

Research output: Contribution to journalArticle

Abstract

Hypoxia-induced mitogenic factor (HIMF), also known as FIZZ1 (found in inflammatory zone), plays important roles in lung inflammation. We found that intraperitoneal injection of lipopolysaccharide (LPS) induced intensive HIMF production exclusively in mouse lung, but not in the heart, liver, spleen or kidney. This HIMF production, at least partly, contributes to LPS-induced vascular cell adhesion molecule-1 (VCAM-1) upregulation and mononuclear cell sequestration to lung parenchyma, while protecting alveolar type II cells from LPS-resulted decrease in surfactant protein-C production and cell death. These data indicate that HIMF participates in LPS-induced acute lung injury and inflammation through modulating VCAM-1 and SP-C expression.

Original languageEnglish (US)
Pages (from-to)2207-2215
Number of pages9
JournalFEBS Letters
Volume580
Issue number9
DOIs
StatePublished - Apr 17 2006

Fingerprint

Acute Lung Injury
Lipopolysaccharides
Up-Regulation
Vascular Cell Adhesion Molecule-1
Pneumonia
Alveolar Epithelial Cells
Lung
Cell death
Protein C
Intraperitoneal Injections
Surface-Active Agents
Liver
Cell Death
Spleen
Kidney
Hypoxia

Keywords

  • Acute lung injury
  • Gene expression
  • Hypoxia-induced mitogenic factor
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Upregulation of hypoxia-induced mitogenic factor in bacterial lipopolysaccharide-induced acute lung injury. / Tong, Qiangsong; Zheng, Liduan; Kang, Qiaohua; Dodd-o, Jeffrey M; Langer, John; Li, Bo; Wang, Danming; Li, Dechun.

In: FEBS Letters, Vol. 580, No. 9, 17.04.2006, p. 2207-2215.

Research output: Contribution to journalArticle

Tong, Qiangsong ; Zheng, Liduan ; Kang, Qiaohua ; Dodd-o, Jeffrey M ; Langer, John ; Li, Bo ; Wang, Danming ; Li, Dechun. / Upregulation of hypoxia-induced mitogenic factor in bacterial lipopolysaccharide-induced acute lung injury. In: FEBS Letters. 2006 ; Vol. 580, No. 9. pp. 2207-2215.
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