Upper esophageal sphincter abnormalities

Frequent finding on high-resolution esophageal manometry and associated with poorer treatment response in achalasia

Yamile H. Chavez, Maria M. Ciarleglio, John O. Clarke, Monica Nandwani, Ellen Stein, Bani C. Roland

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Abnormalities of the upper esophageal sphincter (UES) on high-resolution esophageal manometry (HREM) have been observed in both symptomatic and asymptomatic individuals and are often interpreted as incidental findings of unclear clinical significance. AIMS: Our primary aims were: (1) to assess the frequency of UES abnormalities in consecutive patients referred for HREM studies; and (2) to characterize the demographics, clinical symptoms, and manometric profiles associated with UES abnormalities as compared with those with normal UES function. MATERIALS AND METHODS: We performed a retrospective study of 200 consecutive patients referred for HREM. Patients were divided into those with normal and abnormal UES function, including impaired relaxation (residual pressure >12 mm Hg), hypertensive (>104 mm Hg), and hypotensive (

Original languageEnglish (US)
JournalJournal of Clinical Gastroenterology
DOIs
StateAccepted/In press - May 22 2014

Fingerprint

Upper Esophageal Sphincter
Esophageal Achalasia
Manometry
Therapeutics
Incidental Findings
Retrospective Studies
Demography
Pressure

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Upper esophageal sphincter abnormalities : Frequent finding on high-resolution esophageal manometry and associated with poorer treatment response in achalasia. / Chavez, Yamile H.; Ciarleglio, Maria M.; Clarke, John O.; Nandwani, Monica; Stein, Ellen; Roland, Bani C.

In: Journal of Clinical Gastroenterology, 22.05.2014.

Research output: Contribution to journalArticle

@article{ca04e4c9f4314fd59a00864fa8c38fe1,
title = "Upper esophageal sphincter abnormalities: Frequent finding on high-resolution esophageal manometry and associated with poorer treatment response in achalasia",
abstract = "BACKGROUND: Abnormalities of the upper esophageal sphincter (UES) on high-resolution esophageal manometry (HREM) have been observed in both symptomatic and asymptomatic individuals and are often interpreted as incidental findings of unclear clinical significance. AIMS: Our primary aims were: (1) to assess the frequency of UES abnormalities in consecutive patients referred for HREM studies; and (2) to characterize the demographics, clinical symptoms, and manometric profiles associated with UES abnormalities as compared with those with normal UES function. MATERIALS AND METHODS: We performed a retrospective study of 200 consecutive patients referred for HREM. Patients were divided into those with normal and abnormal UES function, including impaired relaxation (residual pressure >12 mm Hg), hypertensive (>104 mm Hg), and hypotensive (",
author = "Chavez, {Yamile H.} and Ciarleglio, {Maria M.} and Clarke, {John O.} and Monica Nandwani and Ellen Stein and Roland, {Bani C.}",
year = "2014",
month = "5",
day = "22",
doi = "10.1097/MCG.0000000000000157",
language = "English (US)",
journal = "Journal of Clinical Gastroenterology",
issn = "0192-0790",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Upper esophageal sphincter abnormalities

T2 - Frequent finding on high-resolution esophageal manometry and associated with poorer treatment response in achalasia

AU - Chavez, Yamile H.

AU - Ciarleglio, Maria M.

AU - Clarke, John O.

AU - Nandwani, Monica

AU - Stein, Ellen

AU - Roland, Bani C.

PY - 2014/5/22

Y1 - 2014/5/22

N2 - BACKGROUND: Abnormalities of the upper esophageal sphincter (UES) on high-resolution esophageal manometry (HREM) have been observed in both symptomatic and asymptomatic individuals and are often interpreted as incidental findings of unclear clinical significance. AIMS: Our primary aims were: (1) to assess the frequency of UES abnormalities in consecutive patients referred for HREM studies; and (2) to characterize the demographics, clinical symptoms, and manometric profiles associated with UES abnormalities as compared with those with normal UES function. MATERIALS AND METHODS: We performed a retrospective study of 200 consecutive patients referred for HREM. Patients were divided into those with normal and abnormal UES function, including impaired relaxation (residual pressure >12 mm Hg), hypertensive (>104 mm Hg), and hypotensive (

AB - BACKGROUND: Abnormalities of the upper esophageal sphincter (UES) on high-resolution esophageal manometry (HREM) have been observed in both symptomatic and asymptomatic individuals and are often interpreted as incidental findings of unclear clinical significance. AIMS: Our primary aims were: (1) to assess the frequency of UES abnormalities in consecutive patients referred for HREM studies; and (2) to characterize the demographics, clinical symptoms, and manometric profiles associated with UES abnormalities as compared with those with normal UES function. MATERIALS AND METHODS: We performed a retrospective study of 200 consecutive patients referred for HREM. Patients were divided into those with normal and abnormal UES function, including impaired relaxation (residual pressure >12 mm Hg), hypertensive (>104 mm Hg), and hypotensive (

UR - http://www.scopus.com/inward/record.url?scp=84900893483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900893483&partnerID=8YFLogxK

U2 - 10.1097/MCG.0000000000000157

DO - 10.1097/MCG.0000000000000157

M3 - Article

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

SN - 0192-0790

ER -