Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy

Lasya Gaur, Alexander Hanna, W. Patricia Bandettini, Kenneth H. Fischbeck, Andrew E. Arai, Ami Mankodi

Research output: Contribution to journalArticle

Abstract

We analyzed quantitative maps of T1 and T2 relaxation times and muscle fat fraction measurements in magnetic resonance imaging of the upper arm skeletal muscles and heart in ambulatory boys with Duchenne muscular dystrophy and age-range-matched healthy volunteer boys. The cardiac-optimized sequences detected fatty infiltration and edema in the upper arm skeletal muscles but not the myocardium in these Duchenne muscular dystrophy boys who had normal ejection fraction. Imaging the heart and skeletal muscle using the same magnetic resonance imaging methods during a single scan may be useful in assessing relative disease status and therapeutic response in clinical trials of Duchenne muscular dystrophy.

Original languageEnglish (US)
Pages (from-to)948-955
Number of pages8
JournalAnnals of Clinical and Translational Neurology
Volume3
Issue number12
DOIs
StatePublished - Dec 1 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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