Upper airway inflammatory diseases and bronchial hyperresponsiveness

Peyton A. Eggleston

Research output: Contribution to journalArticle

Abstract

Inflammatory processes of the upper airway may alter the responsiveness of the lower airway. For example, bronchial hyperresponsiveness may be seen in patients with allergic rhinitis. This could represent coexistent but unrecognized asthma, but also suggests that IgE-dependent inflammation may occur in the lower airway that can increase bronchial hyperresponsiveness without at the same time precipitating obvious obstruction. Clearly, allergic rhinitis is a risk factor for asthma. A second example of the interaction of upper airway inflammation and bronchial hyperreactivity are reports that viral upper respiratory tract infections may cause otherwise healthy persons to respond abnormally to inhaled histamine or irritants for several months after the infections. These same viruses usually precipitate attacks in patients with asthma, who already have hyperresponsive airways. Both of these examples suggest that inflammatory processes occurring totally or primarily in the upper airway may participate in the pathogenesis of lower respiratory tract hyperresponsiveness and asthma.

Original languageEnglish (US)
Pages (from-to)1036-1041
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Volume81
Issue number5 PART 2
DOIs
StatePublished - 1988

Fingerprint

Bronchial Diseases
Asthma
Inflammation
Bronchial Hyperreactivity
Irritants
Respiratory Tract Infections
Respiratory System
Immunoglobulin E
Histamine
Viruses
Infection

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Upper airway inflammatory diseases and bronchial hyperresponsiveness. / Eggleston, Peyton A.

In: The Journal of Allergy and Clinical Immunology, Vol. 81, No. 5 PART 2, 1988, p. 1036-1041.

Research output: Contribution to journalArticle

@article{b7c4dc7b330b4430bcf9364729b7c04c,
title = "Upper airway inflammatory diseases and bronchial hyperresponsiveness",
abstract = "Inflammatory processes of the upper airway may alter the responsiveness of the lower airway. For example, bronchial hyperresponsiveness may be seen in patients with allergic rhinitis. This could represent coexistent but unrecognized asthma, but also suggests that IgE-dependent inflammation may occur in the lower airway that can increase bronchial hyperresponsiveness without at the same time precipitating obvious obstruction. Clearly, allergic rhinitis is a risk factor for asthma. A second example of the interaction of upper airway inflammation and bronchial hyperreactivity are reports that viral upper respiratory tract infections may cause otherwise healthy persons to respond abnormally to inhaled histamine or irritants for several months after the infections. These same viruses usually precipitate attacks in patients with asthma, who already have hyperresponsive airways. Both of these examples suggest that inflammatory processes occurring totally or primarily in the upper airway may participate in the pathogenesis of lower respiratory tract hyperresponsiveness and asthma.",
author = "Eggleston, {Peyton A.}",
year = "1988",
doi = "10.1016/0091-6749(88)90176-5",
language = "English (US)",
volume = "81",
pages = "1036--1041",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "5 PART 2",

}

TY - JOUR

T1 - Upper airway inflammatory diseases and bronchial hyperresponsiveness

AU - Eggleston, Peyton A.

PY - 1988

Y1 - 1988

N2 - Inflammatory processes of the upper airway may alter the responsiveness of the lower airway. For example, bronchial hyperresponsiveness may be seen in patients with allergic rhinitis. This could represent coexistent but unrecognized asthma, but also suggests that IgE-dependent inflammation may occur in the lower airway that can increase bronchial hyperresponsiveness without at the same time precipitating obvious obstruction. Clearly, allergic rhinitis is a risk factor for asthma. A second example of the interaction of upper airway inflammation and bronchial hyperreactivity are reports that viral upper respiratory tract infections may cause otherwise healthy persons to respond abnormally to inhaled histamine or irritants for several months after the infections. These same viruses usually precipitate attacks in patients with asthma, who already have hyperresponsive airways. Both of these examples suggest that inflammatory processes occurring totally or primarily in the upper airway may participate in the pathogenesis of lower respiratory tract hyperresponsiveness and asthma.

AB - Inflammatory processes of the upper airway may alter the responsiveness of the lower airway. For example, bronchial hyperresponsiveness may be seen in patients with allergic rhinitis. This could represent coexistent but unrecognized asthma, but also suggests that IgE-dependent inflammation may occur in the lower airway that can increase bronchial hyperresponsiveness without at the same time precipitating obvious obstruction. Clearly, allergic rhinitis is a risk factor for asthma. A second example of the interaction of upper airway inflammation and bronchial hyperreactivity are reports that viral upper respiratory tract infections may cause otherwise healthy persons to respond abnormally to inhaled histamine or irritants for several months after the infections. These same viruses usually precipitate attacks in patients with asthma, who already have hyperresponsive airways. Both of these examples suggest that inflammatory processes occurring totally or primarily in the upper airway may participate in the pathogenesis of lower respiratory tract hyperresponsiveness and asthma.

UR - http://www.scopus.com/inward/record.url?scp=0023889915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023889915&partnerID=8YFLogxK

U2 - 10.1016/0091-6749(88)90176-5

DO - 10.1016/0091-6749(88)90176-5

M3 - Article

C2 - 3286731

AN - SCOPUS:0023889915

VL - 81

SP - 1036

EP - 1041

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5 PART 2

ER -