Upfront molecular profiling of pancreatic cancer patients – An idea whose time has come

Manoop S. Bhutani, Irina M. Cazacu, Sinchita Roy-Chowdhuri, Anirban Maitra, Michael J. Pishvaian

Research output: Contribution to journalReview articlepeer-review

Abstract

Pancreatic cancer patients have not benefited from survival improvements brought about by personalized medicine in other malignancies. Even though this is the era of precision medicine, unfortunately most clinicians in practice either do not embrace or are unaware of the concept of molecular profiling for pancreatic cancer patients. Improving the grim prognosis of this challenging disease requires a paradigm shift. To exploit all potential therapeutic options in this lethal disease, molecular profiling should be performed ideally at the moment of diagnosis to identify potentially trial-eligible tumoral mutations or support off label use of an agent approved for another indication. This perspective article aims to increase awareness of the importance of upfront molecular profiling for pancreatic cancer patients.

Original languageEnglish (US)
Pages (from-to)391-393
Number of pages3
JournalPancreatology
Volume20
Issue number3
DOIs
StatePublished - Apr 2020
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

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