Updating of visual space across horizontal saccades in cerebellar and thalamic lesion patients

Jutta Peterburs, Benno Koch, Michael Schwarz, Klaus Peter Hoffmann, Irene Daum, Christian Bellebaum

Research output: Contribution to journalArticle

Abstract

Efference copies of motor commands are used to update visual space across saccades, ultimately ensuring transsaccadic constancy of space. Thalamic lesions have been shown to impair efference copy-based saccadic updating in an oculomotor context, i.e., when two successive saccades are required. Moreover, the cerebellum has also been discussed as one possible source of saccade-related efference copy signals. The present study aimed to investigate the effects of thalamic and cerebellar lesions on saccadic updating in a perceptual context. To this end, seven patients with focal cerebellar lesions, seven patients with focal thalamic lesions and 11 healthy controls completed a perceptual localisation task in which the position of a target had to be updated across a single horizontal saccade, while saccade-related event-related potentials (ERPs) were recorded. Contrary to the expectations, localisation precision in both patient groups did not differ from the respective controls. A positive ERP component with centroparietal distribution occurring from about 300 to 500 ms after saccade onset in the updating condition was observed equally pronounced in controls and thalamic lesion patients. In cerebellar lesion patients, there was evidence of a reduction of this relative positivity in the updating condition, particularly for leftward saccades. This finding suggests that cerebellar damage altered the neural processes underlying saccadic updating in a perceptual context without causing overt behavioural deficits.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalCerebellum
Volume12
Issue number1
DOIs
StatePublished - Feb 2013
Externally publishedYes

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Saccades
Evoked Potentials
Cerebellum

Keywords

  • Cerebellum
  • Efference copy
  • Event-related potentials
  • Saccades
  • Spatial remapping
  • Thalamus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Updating of visual space across horizontal saccades in cerebellar and thalamic lesion patients. / Peterburs, Jutta; Koch, Benno; Schwarz, Michael; Hoffmann, Klaus Peter; Daum, Irene; Bellebaum, Christian.

In: Cerebellum, Vol. 12, No. 1, 02.2013, p. 1-15.

Research output: Contribution to journalArticle

Peterburs, Jutta ; Koch, Benno ; Schwarz, Michael ; Hoffmann, Klaus Peter ; Daum, Irene ; Bellebaum, Christian. / Updating of visual space across horizontal saccades in cerebellar and thalamic lesion patients. In: Cerebellum. 2013 ; Vol. 12, No. 1. pp. 1-15.
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