Updates on uterine papillary serous carcinoma

Amanda Nickles Nickles Fader, David Boruta, Alexander B. Olawaiye, Paola A. Gehrig

Research output: Contribution to journalArticlepeer-review


Uterine papillary serous carcinoma (UPSC) is a biologically aggressive subtype of endometrial cancer. Although much less common than its endometrioid carcinoma counterpart, UPSC accounts for a disproportionate number of endometrial cancer-related recurrences and subsequent deaths. Women most often present with postmenopausal vaginal bleeding. In women diagnosed with metastatic disease, ascites, omental implants or a pelvic mass may be present. Local and distant recurrences occur frequently, with extrapelvic relapses being observed most commonly. Although few prospective trials exist, several retrospective series have demonstrated that optimal cytoreduction and adjuvant platinum/taxane-based chemotherapy with or without radiotherapy appears to improve survival. In addition, another approach to the management of UPSC may lie in targeted therapy. This article reviews the recent literature concerning the epidemiology, molecular pathogenesis and management of UPSC.

Original languageEnglish (US)
Pages (from-to)647-657
Number of pages11
JournalExpert Review of Obstetrics and Gynecology
Issue number6
StatePublished - Nov 1 2009
Externally publishedYes


  • endometrial cancer
  • platin/taxane-based chemotherapy
  • radiotherapy
  • surgical staging
  • targeted therapy
  • uterine papillary serous carcinoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Maternity and Midwifery

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