Updates in Chronic Subdural Hematoma: Epidemiology, Etiology, Pathogenesis, Treatment, and Outcome

James Feghali; Wuyang Yang; Judy Huang

doi:10.1016/j.wneu.2020.06.140

Updates in Chronic Subdural Hematoma: Epidemiology, Etiology, Pathogenesis, Treatment, and Outcome

James Feghali, Wuyang Yang, Judy Huang

School of Medicine

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Chronic subdural hematoma (CSDH) is a complex disease with an overall incidence of 1.7–20.6 per 100,000 persons per year and is more commonly encountered in the elderly population. The pathophysiologic cycle of CSDH formation and expansion involves traumatic and inflammatory components that promote the formation of membranes with permeable neovessels. Many drugs targeting different elements of this cycle are being actively investigated as potential therapeutic agents in CSDH. Burr hole craniostomy appears to be the most commonly used procedure for surgical evacuation, and outcomes are generally favorable. Recurrence can occur in 10%–20% of patients and is associated with several clinical and radiographic predictors. Middle meningeal artery embolization represents one of the latest additions to the therapeutic arsenal of cerebrovascular specialists in treating CSDH and is being critically evaluated in numerous ongoing clinical trials.

Original language	English (US)
Pages (from-to)	339-345
Number of pages	7
Journal	World neurosurgery
Volume	141
DOIs	https://doi.org/10.1016/j.wneu.2020.06.140
State	Published - Sep 2020

Keywords

Chronic subdural hematoma
Epidemiology
Etiology
Outcome
Pathogenesis
Treatment

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/j.wneu.2020.06.140

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title = "Updates in Chronic Subdural Hematoma: Epidemiology, Etiology, Pathogenesis, Treatment, and Outcome",

abstract = "Chronic subdural hematoma (CSDH) is a complex disease with an overall incidence of 1.7–20.6 per 100,000 persons per year and is more commonly encountered in the elderly population. The pathophysiologic cycle of CSDH formation and expansion involves traumatic and inflammatory components that promote the formation of membranes with permeable neovessels. Many drugs targeting different elements of this cycle are being actively investigated as potential therapeutic agents in CSDH. Burr hole craniostomy appears to be the most commonly used procedure for surgical evacuation, and outcomes are generally favorable. Recurrence can occur in 10%–20% of patients and is associated with several clinical and radiographic predictors. Middle meningeal artery embolization represents one of the latest additions to the therapeutic arsenal of cerebrovascular specialists in treating CSDH and is being critically evaluated in numerous ongoing clinical trials.",

keywords = "Chronic subdural hematoma, Epidemiology, Etiology, Outcome, Pathogenesis, Treatment",

author = "James Feghali and Wuyang Yang and Judy Huang",

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language = "English (US)",

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T1 - Updates in Chronic Subdural Hematoma

T2 - Epidemiology, Etiology, Pathogenesis, Treatment, and Outcome

AU - Feghali, James

AU - Yang, Wuyang

AU - Huang, Judy

PY - 2020/9

Y1 - 2020/9

N2 - Chronic subdural hematoma (CSDH) is a complex disease with an overall incidence of 1.7–20.6 per 100,000 persons per year and is more commonly encountered in the elderly population. The pathophysiologic cycle of CSDH formation and expansion involves traumatic and inflammatory components that promote the formation of membranes with permeable neovessels. Many drugs targeting different elements of this cycle are being actively investigated as potential therapeutic agents in CSDH. Burr hole craniostomy appears to be the most commonly used procedure for surgical evacuation, and outcomes are generally favorable. Recurrence can occur in 10%–20% of patients and is associated with several clinical and radiographic predictors. Middle meningeal artery embolization represents one of the latest additions to the therapeutic arsenal of cerebrovascular specialists in treating CSDH and is being critically evaluated in numerous ongoing clinical trials.

AB - Chronic subdural hematoma (CSDH) is a complex disease with an overall incidence of 1.7–20.6 per 100,000 persons per year and is more commonly encountered in the elderly population. The pathophysiologic cycle of CSDH formation and expansion involves traumatic and inflammatory components that promote the formation of membranes with permeable neovessels. Many drugs targeting different elements of this cycle are being actively investigated as potential therapeutic agents in CSDH. Burr hole craniostomy appears to be the most commonly used procedure for surgical evacuation, and outcomes are generally favorable. Recurrence can occur in 10%–20% of patients and is associated with several clinical and radiographic predictors. Middle meningeal artery embolization represents one of the latest additions to the therapeutic arsenal of cerebrovascular specialists in treating CSDH and is being critically evaluated in numerous ongoing clinical trials.

KW - Chronic subdural hematoma

KW - Epidemiology

KW - Etiology

KW - Outcome

KW - Pathogenesis

KW - Treatment

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JO - World neurosurgery

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ER -

Updates in Chronic Subdural Hematoma: Epidemiology, Etiology, Pathogenesis, Treatment, and Outcome

Abstract

Keywords

ASJC Scopus subject areas

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