Updated research nosology for HIV-associated neurocognitive disorders

A. Antinori; G. Arendt; J. T. Becker; B. J. Brew; D. A. Byrd; M. Cherner; D. B. Clifford; P. Cinque; L. G. Epstein; K. Goodkin; M. Gisslen; I. Grant; R. K. Heaton; J. Joseph; K. Marder; C. M. Marra; J. C. McArthur; M. Nunn; R. W. Price; L. Pulliam; K. R. Robertson; N. Sacktor; V. Valcour; V. E. Wojna

doi:10.1212/01.WNL.0000287431.88658.8b

Updated research nosology for HIV-associated neurocognitive disorders

A. Antinori, G. Arendt, J. T. Becker, B. J. Brew, D. A. Byrd, M. Cherner, D. B. Clifford, P. Cinque, L. G. Epstein, K. Goodkin, M. Gisslen, I. Grant, R. K. Heaton, J. Joseph, K. Marder, C. M. Marra, J. C. McArthur, M. Nunn, R. W. Price, L. PulliamK. R. Robertson, N. Sacktor, V. Valcour, V. E. Wojna

School of Medicine

Research output: Contribution to journal › Article › peer-review

1656 Scopus citations

Abstract

In 1991, the AIDS Task Force of the American Academy of Neurology published nomenclature and research case definitions to guide the diagnosis of neurologic manifestations of HIV-1 infection. Now, 16 years later, the National Institute of Mental Health and the National Institute of Neurological Diseases and Stroke have charged a working group to critically review the adequacy and utility of these definitional criteria and to identify aspects that require updating. This report represents a majority view, and unanimity was not reached on all points. It reviews our collective experience with HIV-associated neurocognitive disorders (HAND), particularly since the advent of highly active antiretroviral treatment, and their definitional criteria; discusses the impact of comorbidities; and suggests inclusion of the term asymptomatic neurocognitive impairment to categorize individuals with subclinical impairment. An algorithm is proposed to assist in standardized diagnostic classification of HAND.

Original language	English (US)
Pages (from-to)	1789-1799
Number of pages	11
Journal	Neurology
Volume	69
Issue number	18
DOIs	https://doi.org/10.1212/01.WNL.0000287431.88658.8b
State	Published - Oct 2007

ASJC Scopus subject areas

Clinical Neurology

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Antinori, A., Arendt, G., Becker, J. T., Brew, B. J., Byrd, D. A., Cherner, M., Clifford, D. B., Cinque, P., Epstein, L. G., Goodkin, K., Gisslen, M., Grant, I., Heaton, R. K., Joseph, J., Marder, K., Marra, C. M., McArthur, J. C., Nunn, M., Price, R. W., ... Wojna, V. E. (2007). Updated research nosology for HIV-associated neurocognitive disorders. Neurology, 69(18), 1789-1799. https://doi.org/10.1212/01.WNL.0000287431.88658.8b

Antinori, A, Arendt, G, Becker, JT, Brew, BJ, Byrd, DA, Cherner, M, Clifford, DB, Cinque, P, Epstein, LG, Goodkin, K, Gisslen, M, Grant, I, Heaton, RK, Joseph, J, Marder, K, Marra, CM, McArthur, JC, Nunn, M, Price, RW, Pulliam, L, Robertson, KR, Sacktor, N, Valcour, V & Wojna, VE 2007, 'Updated research nosology for HIV-associated neurocognitive disorders', Neurology, vol. 69, no. 18, pp. 1789-1799. https://doi.org/10.1212/01.WNL.0000287431.88658.8b

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author = "A. Antinori and G. Arendt and Becker, {J. T.} and Brew, {B. J.} and Byrd, {D. A.} and M. Cherner and Clifford, {D. B.} and P. Cinque and Epstein, {L. G.} and K. Goodkin and M. Gisslen and I. Grant and Heaton, {R. K.} and J. Joseph and K. Marder and Marra, {C. M.} and McArthur, {J. C.} and M. Nunn and Price, {R. W.} and L. Pulliam and Robertson, {K. R.} and N. Sacktor and V. Valcour and Wojna, {V. E.}",

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AU - Gisslen, M.

AU - Grant, I.

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AU - Joseph, J.

AU - Marder, K.

AU - Marra, C. M.

AU - McArthur, J. C.

AU - Nunn, M.

AU - Price, R. W.

AU - Pulliam, L.

AU - Robertson, K. R.

AU - Sacktor, N.

AU - Valcour, V.

AU - Wojna, V. E.

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Updated research nosology for HIV-associated neurocognitive disorders

Abstract

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