Update on treatment advances in combined-modality therapy for anal and rectal carcinomas

Jeffrey Meyer, Glen Balch, Christopher Willett, Brian Czito

Research output: Contribution to journalReview article


Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy regimens in an effort to maximize tumor responses while reducing normal tissue toxicity. This review will discuss established regimens as well as newer and novel treatment approaches to treatment of anal and rectal cancer.

Original languageEnglish (US)
Pages (from-to)177-185
Number of pages9
JournalCurrent oncology reports
Issue number3
StatePublished - Jun 1 2011
Externally publishedYes



  • Anal cancer
  • Chemotherapy
  • Combined modality
  • Radiation
  • Rectal cancer

ASJC Scopus subject areas

  • Oncology

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