Update on the Neuropsychiatry of Substance Use Disorders

George Kolodner, Vassilis E. Koliatsos

Research output: Contribution to journalReview articlepeer-review


This article reviews some of the recent discoveries about how neurobiological processes contribute to the understanding and treatment of substance use disorders. Particular focus is given to cannabis, opioids, and designer drugs. Important areas addressed include triggers and cravings, the central roles of dopamine and stress, and the endocannabinoid system. Clinical relevance of these findings for withdrawal management and relapse prevention is discussed. Also highlighted are issues related to the opioid epidemic and consequences both of continuing federal prohibition of cannabis as well as its state-by-state relaxation.

Original languageEnglish (US)
Pages (from-to)291-304
Number of pages14
JournalPsychiatric Clinics of North America
Issue number2
StatePublished - Jun 2020


  • Acamprosate
  • Buprenorphine
  • Cannabis
  • Craving
  • Drugs
  • Naltrexone
  • Opioids
  • Substance use disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health


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