Update on newer antihypertensive medicines and interventions

Research output: Contribution to journalArticle

Abstract

The incidence and prevalence of systemic hypertension are reaching global epidemic proportions. Despite a diverse pharmacologic armamentarium of agents to treat high blood pressure, suboptimal control remains a significant problem in as many as 43% of patients and this rate has not significantly improved over the past 2 decades. There are a variety of factors contributing to this including patient nonadherence due to complex drug regimens and medication side effects, undertreatment, and treatment resistance. There, thus, remains a need to develop novel agents and approaches to antihypertensive therapy that facilitate attainment of optimal blood pressure levels. This monograph will review a number of new pharmacologic targets and interventions as well as a novel method of drug delivery to patients.

Original languageEnglish (US)
Pages (from-to)257-267
Number of pages11
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume15
Issue number3
DOIs
StatePublished - Sep 2010

Fingerprint

Antihypertensive Agents
Hypertension
Patient Compliance
Pharmaceutical Preparations
Blood Pressure
Incidence
Therapeutics

Keywords

  • antihypertensives
  • drug effects
  • hypertension
  • renin-angiotensin system

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "The incidence and prevalence of systemic hypertension are reaching global epidemic proportions. Despite a diverse pharmacologic armamentarium of agents to treat high blood pressure, suboptimal control remains a significant problem in as many as 43{\%} of patients and this rate has not significantly improved over the past 2 decades. There are a variety of factors contributing to this including patient nonadherence due to complex drug regimens and medication side effects, undertreatment, and treatment resistance. There, thus, remains a need to develop novel agents and approaches to antihypertensive therapy that facilitate attainment of optimal blood pressure levels. This monograph will review a number of new pharmacologic targets and interventions as well as a novel method of drug delivery to patients.",
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