Update on neuroblastoma

On behalf of the APSA Cancer committee

doi:10.1016/j.jpedsurg.2018.09.004

Update on neuroblastoma

On behalf of the APSA Cancer committee

School of Medicine

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Neuroblastoma is an embryonic cancer arising from neural crest stem cells. This cancer is the most common malignancy in infants and the most common extracranial solid tumor in children. The clinical course may be highly variable with the possibility of spontaneous regression in the youngest patients and increased risk of aggressive disease in older children. Clinical heterogeneity is a consequence of the diverse biologic characteristics that determine patient risk and survival. This review will focus on current progress in neuroblastoma staging, risk stratification, and treatment strategies based on advancing knowledge in tumor biology and genetic characterization. Type of study: Review article. Level of evidence: Level II.

Original language	English (US)
Pages (from-to)	383-389
Number of pages	7
Journal	Journal of pediatric surgery
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/j.jpedsurg.2018.09.004
State	Published - Mar 2019

Keywords

Cancer
Neuroblastoma
Oncology
Solid tumor
Surgery
Treatment

ASJC Scopus subject areas

Surgery
Pediatrics, Perinatology, and Child Health

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10.1016/j.jpedsurg.2018.09.004

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title = "Update on neuroblastoma",

abstract = "Neuroblastoma is an embryonic cancer arising from neural crest stem cells. This cancer is the most common malignancy in infants and the most common extracranial solid tumor in children. The clinical course may be highly variable with the possibility of spontaneous regression in the youngest patients and increased risk of aggressive disease in older children. Clinical heterogeneity is a consequence of the diverse biologic characteristics that determine patient risk and survival. This review will focus on current progress in neuroblastoma staging, risk stratification, and treatment strategies based on advancing knowledge in tumor biology and genetic characterization. Type of study: Review article. Level of evidence: Level II.",

keywords = "Cancer, Neuroblastoma, Oncology, Solid tumor, Surgery, Treatment",

author = "{On behalf of the APSA Cancer committee} and Newman, {Erika A.} and Shahab Abdessalam and Aldrink, {Jennifer H.} and Mary Austin and Heaton, {Todd E.} and Jennifer Bruny and Peter Ehrlich and Roshni Dasgupta and Baertschiger, {Reto M.} and Lautz, {Timothy B.} and Rhee, {Daniel S.} and Langham, {Max R.} and Malek, {Marcus M.} and Meyers, {Rebecka L.} and Nathan, {Jaimie D.} and Weil, {Brent R.} and Stephanie Polites and Madonna, {Mary Beth}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = mar,

doi = "10.1016/j.jpedsurg.2018.09.004",

language = "English (US)",

volume = "54",

pages = "383--389",

journal = "Journal of pediatric surgery",

issn = "0022-3468",

publisher = "W.B. Saunders Ltd",

number = "3",

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TY - JOUR

T1 - Update on neuroblastoma

AU - On behalf of the APSA Cancer committee

AU - Newman, Erika A.

AU - Abdessalam, Shahab

AU - Aldrink, Jennifer H.

AU - Austin, Mary

AU - Heaton, Todd E.

AU - Bruny, Jennifer

AU - Ehrlich, Peter

AU - Dasgupta, Roshni

AU - Baertschiger, Reto M.

AU - Lautz, Timothy B.

AU - Rhee, Daniel S.

AU - Langham, Max R.

AU - Malek, Marcus M.

AU - Meyers, Rebecka L.

AU - Nathan, Jaimie D.

AU - Weil, Brent R.

AU - Polites, Stephanie

AU - Madonna, Mary Beth

PY - 2019/3

Y1 - 2019/3

N2 - Neuroblastoma is an embryonic cancer arising from neural crest stem cells. This cancer is the most common malignancy in infants and the most common extracranial solid tumor in children. The clinical course may be highly variable with the possibility of spontaneous regression in the youngest patients and increased risk of aggressive disease in older children. Clinical heterogeneity is a consequence of the diverse biologic characteristics that determine patient risk and survival. This review will focus on current progress in neuroblastoma staging, risk stratification, and treatment strategies based on advancing knowledge in tumor biology and genetic characterization. Type of study: Review article. Level of evidence: Level II.

AB - Neuroblastoma is an embryonic cancer arising from neural crest stem cells. This cancer is the most common malignancy in infants and the most common extracranial solid tumor in children. The clinical course may be highly variable with the possibility of spontaneous regression in the youngest patients and increased risk of aggressive disease in older children. Clinical heterogeneity is a consequence of the diverse biologic characteristics that determine patient risk and survival. This review will focus on current progress in neuroblastoma staging, risk stratification, and treatment strategies based on advancing knowledge in tumor biology and genetic characterization. Type of study: Review article. Level of evidence: Level II.

KW - Cancer

KW - Neuroblastoma

KW - Oncology

KW - Solid tumor

KW - Surgery

KW - Treatment

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U2 - 10.1016/j.jpedsurg.2018.09.004

DO - 10.1016/j.jpedsurg.2018.09.004

M3 - Review article

C2 - 30305231

AN - SCOPUS:85054462809

SN - 0022-3468

VL - 54

SP - 383

EP - 389

JO - Journal of pediatric surgery

JF - Journal of pediatric surgery

IS - 3

ER -

Update on neuroblastoma

Abstract

Keywords

ASJC Scopus subject areas

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