Update on anti-phospholipid antibodies in SLE: The Hopkins Lupus Cohort

Research output: Contribution to journalReview article

Abstract

Anti-phospholipid antibodies are common in patients in the Hopkins Lupus Cohort: 47% have anti-cardiolipin, 32.5% anti-β2-glycoprotein I and 26% lupus anticoagulant (by dRVVT confirmatory testing). Systemic lupus erythematosus patients with the lupus anticoagulant at baseline have a 50% chance of a deep venous thrombosis/pulmonary embolus in the next 20 years. Anti-phospholipid antibodies differ in their association with thrombosis: the lupus anticoagulant is most strongly associated with arterial and venous thrombosis and is the only anti-phospholipid antibody associated with myocardial infarction. Anti-phospholipid antibodies are not associated with atherosclerosis.

Original languageEnglish (US)
Pages (from-to)419-423
Number of pages5
JournalLupus
Volume19
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • Anti-cardiolipin antibodies
  • Anti-phospholipid syndrome
  • Lupus anticoagulant

ASJC Scopus subject areas

  • Rheumatology

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