Update in the Diagnosis and Management of Central Nervous System Infections

Wendy C Ziai, John J. Lewin

Research output: Contribution to journalArticle

Abstract

Central nervous system (CNS) infections presenting to the emergency room include meningitis, encephalitis, brain and spinal epidural abscess, subdural empyema, and ventriculitis. These conditions often require admission to an intensive care unit (ICU) and are complications of ICU patients with neurologic injury, contributing significantly to morbidity and mortality. Reducing morbidity and mortality is critically dependent on rapid diagnosis and, perhaps more importantly, on the timely initiation of appropriate antimicrobial therapy. New insights into the role of inflammation and the immune response in CNS infections have contributed to development of new diagnostic strategies using markers of inflammation, and to the study of agents with focused immunomodulatory activity, which may lead to further adjunctive therapy in human disease.

Original languageEnglish (US)
Pages (from-to)427-468
Number of pages42
JournalNeurologic Clinics
Volume26
Issue number2
DOIs
StatePublished - May 2008

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Central Nervous System Infections
Intensive Care Units
Subdural Empyema
Epidural Abscess
Inflammation
Morbidity
Nervous System Trauma
Mortality
Encephalitis
Meningitis
Hospital Emergency Service
Brain
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Update in the Diagnosis and Management of Central Nervous System Infections. / Ziai, Wendy C; Lewin, John J.

In: Neurologic Clinics, Vol. 26, No. 2, 05.2008, p. 427-468.

Research output: Contribution to journalArticle

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