TY - JOUR
T1 - Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours
T2 - Oropharynx
AU - Westra, William H.
AU - Lewis, James S.
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - The changes for oropharyngeal lesions in the 2017 edition of the WHO/IARC Classification of Head and Neck Tumours reference book are dramatic and significant, largely due to the growing impact of high risk human papillomavirus (HPV). The upcoming edition divides tumours of the oral cavity and oropharynx into separate chapters, classifies squamous cell carcinomas (SCC) of the oropharynx on the basis of HPV status, abandons the practice of histologic grading for oropharyngeal SCCs that are HPV positive, recognizes small cell carcinoma of the oropharynx, and combines polymorphous low grade adenocarcinoma and cribriform adenocarcinoma of tongue and minor salivary glands under the single term “polymorphous adenocarcinoma.” This review not only calls attention to these changes, but describes the rationale driving these changes and highlights their implications for routine clinical practice.
AB - The changes for oropharyngeal lesions in the 2017 edition of the WHO/IARC Classification of Head and Neck Tumours reference book are dramatic and significant, largely due to the growing impact of high risk human papillomavirus (HPV). The upcoming edition divides tumours of the oral cavity and oropharynx into separate chapters, classifies squamous cell carcinomas (SCC) of the oropharynx on the basis of HPV status, abandons the practice of histologic grading for oropharyngeal SCCs that are HPV positive, recognizes small cell carcinoma of the oropharynx, and combines polymorphous low grade adenocarcinoma and cribriform adenocarcinoma of tongue and minor salivary glands under the single term “polymorphous adenocarcinoma.” This review not only calls attention to these changes, but describes the rationale driving these changes and highlights their implications for routine clinical practice.
KW - Human papillomavirus
KW - Oropharynx
KW - Polymorphous adenocarcinoma
KW - Small cell carcinoma
KW - Squamous cell carcinoma
KW - World Health Organization
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U2 - 10.1007/s12105-017-0793-2
DO - 10.1007/s12105-017-0793-2
M3 - Article
C2 - 28247229
AN - SCOPUS:85013999520
SN - 1936-055X
VL - 11
SP - 41
EP - 47
JO - Head and Neck Pathology
JF - Head and Neck Pathology
IS - 1
ER -