Abstract
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding glucose transporters, glycolytic enzymes, and vascular endothelial growth factor (VEGF). HIF-1α is a major subunit of HIF-1 heterodimer. In this study, an immunohistochemical analysis of HIF-1α was focused on clinical specimens containing high-grade prostate intraepithelial neoplasia lesions since high-grade prostate intraepithelial neoplasia is considered the precursor of a majority of invasive prostate adenocarcinoma and presents the increased activity of angiogenesis. HIF-1α was up-regulated in 11 of 14 high-grade prostate intraepithelial neoplasia lesions identified in a total 10 prostate biopsies relative to the respective normal epithelium, stromal cells, and benign prostatic hyperplasia (BPH). Moreover, up-regulation of HIF-1α in adjacent prostate cancer lesions was more enhanced than in high-grade prostate intraepithelial neoplasia. The results suggest that up-regulation of HIF-1α is an early event in prostate carcinogenesis, and that HIF-1α may become a potential target for prostate cancer prevention and a surrogate biomarker for monitoring pre-malignant lesions of the prostate.
Original language | English (US) |
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Pages (from-to) | 88-93 |
Number of pages | 6 |
Journal | Cancer detection and prevention |
Volume | 28 |
Issue number | 2 |
DOIs | |
State | Published - 2004 |
Keywords
- BPH
- Benign prostatic hyperplasia
- HG-PIN
- HIF-1
- High-grade PIN
- Hypoxia-inducible factor 1
- IGF
- Insulin-like growth factor
- PCA
- PIN
- Prostate
- Prostatic adenocarcinoma
- Prostatic intraepithelial neoplasia
- VEGF
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Oncology
- Cancer Research