Unusual serological findings associated with ceftriaxone-induced immune hemolytic anemia in a child with disseminated low-grade glioma

Lydia Pecker, A. Timsar, P. P. Pary, G. A. Denomme, V. R. Criss, N. L C Luban, E. I. Hwang, E. C C Wong

Research output: Contribution to journalArticle

Abstract

Ceftriaxone-induced immune hemolytic anemia (CIHA) is the second most common cause of drug-induced hemolytic anemia. Prompt recognition of this drug reaction is essential because brisk hemolysis can be deadly. The extent to which ceftriaxone antibodies persist after CIHA is unknown; rechallenging patients who have experienced CIHA is not recommended. We report a case of CIHA in a neurooncology patient, which is the first to show anticeftriaxone antibodies with Rh specificity and persisted for 8 months after the drug reaction. These findings have implications for understanding the mechanism of CIHA.

Original languageEnglish (US)
Pages (from-to)1852-1855
Number of pages4
JournalPediatric Blood and Cancer
Volume63
Issue number10
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

Keywords

  • anemias
  • blood bank
  • immune cytopenias
  • transfusion medicine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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    Pecker, L., Timsar, A., Pary, P. P., Denomme, G. A., Criss, V. R., Luban, N. L. C., Hwang, E. I., & Wong, E. C. C. (2016). Unusual serological findings associated with ceftriaxone-induced immune hemolytic anemia in a child with disseminated low-grade glioma. Pediatric Blood and Cancer, 63(10), 1852-1855. https://doi.org/10.1002/pbc.26101