Abstract
Objective: To report a rare case of metastatic growth hormone (GH)-secreting pituitary carcinoma causing acromegaly. Methods: We present a case report and review the available literature on this topic. Results: A 68-year-old woman presented with persistent acromegaly after treatment for a GH-secreting pituitary adenoma. Evaluation of long-standing cervical adenopathy revealed findings consistent with a metastatic neuroendocrine tumor. Further work-up revealed additional thyroid, parathyroid, and cervical masses. After operative treatment including total thyroidectomy, subtotal parathyroidectomy, partial thymectomy, and right modified radical neck dissection, the patient's symptoms diminished, and her GH levels approached the normal range. Surgical pathology findings were consistent with a GH-secreting pituitary carcinoma metastatic to the cervical lymph nodes, multinodular thyroid hyperplasia with a focus of papillary microcarcinoma, and parathyroid hyperplasia. Conclusion: Overall, pituitary carcinomas are extremely rare. To date, about 100 cases have been reported in the world's literature, and of these, only 19 cases originated from GH-secreting cells. Our examination of the symptoms, signs, diagnosis, and treatment of our patient, in comparison with the previously reported cases, should enhance awareness of this unusual disease process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 72-76 |
| Number of pages | 5 |
| Journal | Endocrine Practice |
| Volume | 13 |
| Issue number | 1 |
| State | Published - Jan 2007 |
Fingerprint
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Unusual case of metastatic neuroendocrine tumor. / Manahan, Michele; Dackiw, Alan P B; Ball, Douglas W; Zeiger, Martha A.
In: Endocrine Practice, Vol. 13, No. 1, 01.2007, p. 72-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unusual case of metastatic neuroendocrine tumor
AU - Manahan, Michele
AU - Dackiw, Alan P B
AU - Ball, Douglas W
AU - Zeiger, Martha A.
PY - 2007/1
Y1 - 2007/1
N2 - Objective: To report a rare case of metastatic growth hormone (GH)-secreting pituitary carcinoma causing acromegaly. Methods: We present a case report and review the available literature on this topic. Results: A 68-year-old woman presented with persistent acromegaly after treatment for a GH-secreting pituitary adenoma. Evaluation of long-standing cervical adenopathy revealed findings consistent with a metastatic neuroendocrine tumor. Further work-up revealed additional thyroid, parathyroid, and cervical masses. After operative treatment including total thyroidectomy, subtotal parathyroidectomy, partial thymectomy, and right modified radical neck dissection, the patient's symptoms diminished, and her GH levels approached the normal range. Surgical pathology findings were consistent with a GH-secreting pituitary carcinoma metastatic to the cervical lymph nodes, multinodular thyroid hyperplasia with a focus of papillary microcarcinoma, and parathyroid hyperplasia. Conclusion: Overall, pituitary carcinomas are extremely rare. To date, about 100 cases have been reported in the world's literature, and of these, only 19 cases originated from GH-secreting cells. Our examination of the symptoms, signs, diagnosis, and treatment of our patient, in comparison with the previously reported cases, should enhance awareness of this unusual disease process.
AB - Objective: To report a rare case of metastatic growth hormone (GH)-secreting pituitary carcinoma causing acromegaly. Methods: We present a case report and review the available literature on this topic. Results: A 68-year-old woman presented with persistent acromegaly after treatment for a GH-secreting pituitary adenoma. Evaluation of long-standing cervical adenopathy revealed findings consistent with a metastatic neuroendocrine tumor. Further work-up revealed additional thyroid, parathyroid, and cervical masses. After operative treatment including total thyroidectomy, subtotal parathyroidectomy, partial thymectomy, and right modified radical neck dissection, the patient's symptoms diminished, and her GH levels approached the normal range. Surgical pathology findings were consistent with a GH-secreting pituitary carcinoma metastatic to the cervical lymph nodes, multinodular thyroid hyperplasia with a focus of papillary microcarcinoma, and parathyroid hyperplasia. Conclusion: Overall, pituitary carcinomas are extremely rare. To date, about 100 cases have been reported in the world's literature, and of these, only 19 cases originated from GH-secreting cells. Our examination of the symptoms, signs, diagnosis, and treatment of our patient, in comparison with the previously reported cases, should enhance awareness of this unusual disease process.
UR - http://www.scopus.com/inward/record.url?scp=34147124456&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147124456&partnerID=8YFLogxK
M3 - Article
C2 - 17360306
AN - SCOPUS:34147124456
VL - 13
SP - 72
EP - 76
JO - Endocrine Practice
JF - Endocrine Practice
SN - 1530-891X
IS - 1
ER -