@article{263460caf0954b379d760e9304b0e65d,
title = "Unusual cardiac, renal and pulmonary involvement in Gaucher's disease. Interstitial glucocerebroside accumulation, pulmonary hypertension and fatal bone marrow embolization",
abstract = "A 25 year old black woman who had manifestations of Gaucher's disease since one year of age is described. This patient had clinically significant cardiac, renal and pulmonary involvement with Gaucher's disease. Interstitial infiltration of the myocardium by Gaucher cells caused decreased left ventricular compliance and decreased cardiac output. In the kidney, Gaucher cells were present in the mesangium of the glomeruli and the interstitium of the cortex. Also, electron dense, intramembranous granular deposits were seen in glomeruli on electron microscopy. The pulmonary findings included pulmonary arterial hypertension, accentuated basilar deposition of glucocerebroside in the interstitium of alveolar septums and fatal bone marrow embolization.",
author = "Smith, {Rober R.L.} and Hutchins, {Grover M.} and Sack, {George H.} and Ridolfi, {Ren L.}",
note = "Funding Information: ROBER R. L. SMITH, M.D. GROVER M. HUTCHINS, M.D. GEORGE H. SACK, Jr., M.D., Ph.D{\textquoteright} REN L. RIDOLFI, M.D. Baltimore, Maryland From the Depamnents of Pathology and Medicine, The Johns Hopkins Medical Institution, Baltimore, Maryland. This study was supported by Grants P50-HL-1765504, HL-14153 and 1 RO 1 CA 20619-01 from The National Institutes of Health, Public Health Service, Department of Health, Education and Welfare. Requests for reprints should be addressed to Dr. Grover M. Hutchins, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21205. Manuscript accepted March 2, 1979. l Andrew Mellon Scholar in Medicine.",
year = "1978",
month = aug,
doi = "10.1016/0002-9343(78)90832-X",
language = "English (US)",
volume = "65",
pages = "352--360",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "2",
}