Unusual cardiac malformations in splenogonadal fusion-peromelia syndrome: Relationship to normal development

K. F. Loomis, G. W. Moore, G. M. Hutchins

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A male newborn infant, studied at autopsy, showed continuous splenogonadal fusion and severe peromelia associated with an unusual, possibly unique, cardiac malformation complex. The cardiac lesions included multiple right ventricle diverticula, tricuspid atresia, mitral to semilunar valve discontinuity, and absent muscular outflow tract septum. Tabulation of the time of appearance of relevant anatomic features in 351 normal human embryos of Carnegie stages 9 through 23 showed that the teratogenic influence in the present case probably occurred by stages 16-17. The nature and distribution of lesions observed suggest that proliferating undifferentiated mesenchyme was the target of the unknown injury.

    Original languageEnglish (US)
    Pages (from-to)1-9
    Number of pages9
    JournalTeratology
    Volume25
    Issue number1
    StatePublished - 1982

    ASJC Scopus subject areas

    • Developmental Biology
    • Health, Toxicology and Mutagenesis
    • Embryology
    • Toxicology

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