Untreated primary lung and breast cancers: Correlation between F-18 FDG kinetic rate constants and findings of in vitro studies

Tatsuo Torizuka, Kenneth R. Zasadny, Betty Recker, Richard L. Wahl

Research output: Contribution to journalArticle

Abstract

PURPOSE: To compare the kinetic modeling of 2-[fluorine-18]fluoro-2- deoxy-D-glucose (F-18 FDG) between untreated primary lung and untreated primary breast cancers by using position emission tomographic (PET) findings and to correlate the findings with findings of in vitro studies. MATERIALS AND METHODS: Nineteen patients (12 men, seven women; age range, 49-82 years) with untreated primary lung cancer and 17 women with untreated primary breast cancer (age range, 26-65 years) underwent 1-hour dynamic F-18 FDG PET. A three-compartment model was applied to F-18 FDG kinetics in tumors. The standard uptake value normalized for lean body mass (SUV(lean)) in tumors was measured 50-60 minutes after tracer injection. In vitro, thin-layer chromatography was performed to evaluate the intracellular phosphorylation of tritiated F-18 FDG in human lung cancer and breast cancer cell lines. RESULTS: At PEt, lung cancer had a significantly (P <.003) higher rate constant for F-18 FDG phosphorylation (k3) and SUV(lean) than did breast cancer (0.161 ± 0.150 [standard deviation] vs 0.043 ± 0.018 and 8.25 ± 3.28 vs 3.17 ± 1.08, respectively). Breast cancer showed a significant correlation between k3 and SUV(lean) (r = .607, P <.01), although no such correlation was observed in lung cancer. In vitro studies showed phosphorylation of F-18 FDG in breast cancer cells was less complete in hyperglycemia than it was in lung cancer cells. CONCLUSION: A much lower k3 appears to be a rate-limiting factor for F-18 FDG accumulation in breast cancer, while the higher k3 in lung cancer is probably not rate limiting for F-18 FDG accumulation.

Original languageEnglish (US)
Pages (from-to)767-774
Number of pages8
JournalRadiology
Volume207
Issue number3
StatePublished - Jun 1998
Externally publishedYes

Fingerprint

Fluorine
Deoxyglucose
Lung Neoplasms
Breast Neoplasms
Phosphorylation
In Vitro Techniques
Thin Layer Chromatography
Hyperglycemia
Neoplasms
Cell Line
Lung
Injections

Keywords

  • Breast neoplasms, emission CT (ECT), 00.12163
  • Breast neoplasms, radionuclide studies, 00.12163, 00.30
  • Flourine
  • LUng neoplasms, emission CT (ECT), 60.12163
  • Lung neoplasms, radionuclide studies, 60.12163, 60.30

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Untreated primary lung and breast cancers : Correlation between F-18 FDG kinetic rate constants and findings of in vitro studies. / Torizuka, Tatsuo; Zasadny, Kenneth R.; Recker, Betty; Wahl, Richard L.

In: Radiology, Vol. 207, No. 3, 06.1998, p. 767-774.

Research output: Contribution to journalArticle

Torizuka, Tatsuo ; Zasadny, Kenneth R. ; Recker, Betty ; Wahl, Richard L. / Untreated primary lung and breast cancers : Correlation between F-18 FDG kinetic rate constants and findings of in vitro studies. In: Radiology. 1998 ; Vol. 207, No. 3. pp. 767-774.
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abstract = "PURPOSE: To compare the kinetic modeling of 2-[fluorine-18]fluoro-2- deoxy-D-glucose (F-18 FDG) between untreated primary lung and untreated primary breast cancers by using position emission tomographic (PET) findings and to correlate the findings with findings of in vitro studies. MATERIALS AND METHODS: Nineteen patients (12 men, seven women; age range, 49-82 years) with untreated primary lung cancer and 17 women with untreated primary breast cancer (age range, 26-65 years) underwent 1-hour dynamic F-18 FDG PET. A three-compartment model was applied to F-18 FDG kinetics in tumors. The standard uptake value normalized for lean body mass (SUV(lean)) in tumors was measured 50-60 minutes after tracer injection. In vitro, thin-layer chromatography was performed to evaluate the intracellular phosphorylation of tritiated F-18 FDG in human lung cancer and breast cancer cell lines. RESULTS: At PEt, lung cancer had a significantly (P <.003) higher rate constant for F-18 FDG phosphorylation (k3) and SUV(lean) than did breast cancer (0.161 ± 0.150 [standard deviation] vs 0.043 ± 0.018 and 8.25 ± 3.28 vs 3.17 ± 1.08, respectively). Breast cancer showed a significant correlation between k3 and SUV(lean) (r = .607, P <.01), although no such correlation was observed in lung cancer. In vitro studies showed phosphorylation of F-18 FDG in breast cancer cells was less complete in hyperglycemia than it was in lung cancer cells. CONCLUSION: A much lower k3 appears to be a rate-limiting factor for F-18 FDG accumulation in breast cancer, while the higher k3 in lung cancer is probably not rate limiting for F-18 FDG accumulation.",
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T1 - Untreated primary lung and breast cancers

T2 - Correlation between F-18 FDG kinetic rate constants and findings of in vitro studies

AU - Torizuka, Tatsuo

AU - Zasadny, Kenneth R.

AU - Recker, Betty

AU - Wahl, Richard L.

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N2 - PURPOSE: To compare the kinetic modeling of 2-[fluorine-18]fluoro-2- deoxy-D-glucose (F-18 FDG) between untreated primary lung and untreated primary breast cancers by using position emission tomographic (PET) findings and to correlate the findings with findings of in vitro studies. MATERIALS AND METHODS: Nineteen patients (12 men, seven women; age range, 49-82 years) with untreated primary lung cancer and 17 women with untreated primary breast cancer (age range, 26-65 years) underwent 1-hour dynamic F-18 FDG PET. A three-compartment model was applied to F-18 FDG kinetics in tumors. The standard uptake value normalized for lean body mass (SUV(lean)) in tumors was measured 50-60 minutes after tracer injection. In vitro, thin-layer chromatography was performed to evaluate the intracellular phosphorylation of tritiated F-18 FDG in human lung cancer and breast cancer cell lines. RESULTS: At PEt, lung cancer had a significantly (P <.003) higher rate constant for F-18 FDG phosphorylation (k3) and SUV(lean) than did breast cancer (0.161 ± 0.150 [standard deviation] vs 0.043 ± 0.018 and 8.25 ± 3.28 vs 3.17 ± 1.08, respectively). Breast cancer showed a significant correlation between k3 and SUV(lean) (r = .607, P <.01), although no such correlation was observed in lung cancer. In vitro studies showed phosphorylation of F-18 FDG in breast cancer cells was less complete in hyperglycemia than it was in lung cancer cells. CONCLUSION: A much lower k3 appears to be a rate-limiting factor for F-18 FDG accumulation in breast cancer, while the higher k3 in lung cancer is probably not rate limiting for F-18 FDG accumulation.

AB - PURPOSE: To compare the kinetic modeling of 2-[fluorine-18]fluoro-2- deoxy-D-glucose (F-18 FDG) between untreated primary lung and untreated primary breast cancers by using position emission tomographic (PET) findings and to correlate the findings with findings of in vitro studies. MATERIALS AND METHODS: Nineteen patients (12 men, seven women; age range, 49-82 years) with untreated primary lung cancer and 17 women with untreated primary breast cancer (age range, 26-65 years) underwent 1-hour dynamic F-18 FDG PET. A three-compartment model was applied to F-18 FDG kinetics in tumors. The standard uptake value normalized for lean body mass (SUV(lean)) in tumors was measured 50-60 minutes after tracer injection. In vitro, thin-layer chromatography was performed to evaluate the intracellular phosphorylation of tritiated F-18 FDG in human lung cancer and breast cancer cell lines. RESULTS: At PEt, lung cancer had a significantly (P <.003) higher rate constant for F-18 FDG phosphorylation (k3) and SUV(lean) than did breast cancer (0.161 ± 0.150 [standard deviation] vs 0.043 ± 0.018 and 8.25 ± 3.28 vs 3.17 ± 1.08, respectively). Breast cancer showed a significant correlation between k3 and SUV(lean) (r = .607, P <.01), although no such correlation was observed in lung cancer. In vitro studies showed phosphorylation of F-18 FDG in breast cancer cells was less complete in hyperglycemia than it was in lung cancer cells. CONCLUSION: A much lower k3 appears to be a rate-limiting factor for F-18 FDG accumulation in breast cancer, while the higher k3 in lung cancer is probably not rate limiting for F-18 FDG accumulation.

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KW - Lung neoplasms, radionuclide studies, 60.12163, 60.30

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