Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis

Andrew T. Magis, Noa Rappaport, Matthew P. Conomos, Gilbert S. Omenn, Jennifer C. Lovejoy, Leroy Hood, Nathan D. Price

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed 1196 proteins in longitudinal plasma samples from participants in a commercial wellness program, including samples collected pre-diagnosis from ten cancer patients and 69 controls. For three individuals ultimately diagnosed with metastatic breast, lung, or pancreatic cancer, CEACAM5 was a persistent longitudinal outlier as early as 26.5 months pre-diagnosis. CALCA, a biomarker for medullary thyroid cancer, was hypersecreted in metastatic pancreatic cancer at least 16.5 months pre-diagnosis. ERBB2 levels spiked in metastatic breast cancer between 10.0 and 4.0 months pre-diagnosis. Our results support the value of deep phenotyping seemingly healthy individuals in prospectively inferring disease transitions.

Original languageEnglish (US)
Article number16275
JournalScientific reports
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • General

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